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LGI1 downregulation increases neuronal circuit excitability.
Lugarà E, Kaushik R, Leite M, Chabrol E, Dityatev A, Lignani G, Walker MC. Lugarà E, et al. Epilepsia. 2020 Dec;61(12):2836-2846. doi: 10.1111/epi.16736. Epub 2020 Oct 26. Epilepsia. 2020. PMID: 33104247
Decanoic acid inhibits mTORC1 activity independent of glucose and insulin signaling.
Warren EC, Dooves S, Lugarà E, Damstra-Oddy J, Schaf J, Heine VM, Walker MC, Williams RSB. Warren EC, et al. Among authors: lugara e. Proc Natl Acad Sci U S A. 2020 Sep 22;117(38):23617-23625. doi: 10.1073/pnas.2008980117. Epub 2020 Sep 2. Proc Natl Acad Sci U S A. 2020. PMID: 32879008 Free PMC article.
Foamy Virus Vectors Transduce Visceral Organs and Hippocampal Structures following In Vivo Delivery to Neonatal Mice.
Counsell JR, Karda R, Diaz JA, Carey L, Wiktorowicz T, Buckley SMK, Ameri S, Ng J, Baruteau J, Almeida F, de Silva R, Simone R, Lugarà E, Lignani G, Lindemann D, Rethwilm A, Rahim AA, Waddington SN, Howe SJ. Counsell JR, et al. Among authors: lugara e. Mol Ther Nucleic Acids. 2018 Sep 7;12:626-634. doi: 10.1016/j.omtn.2018.07.006. Epub 2018 Aug 3. Mol Ther Nucleic Acids. 2018. PMID: 30081233 Free PMC article.
microRNA targeting of the P2X7 purinoceptor opposes a contralateral epileptogenic focus in the hippocampus.
Jimenez-Mateos EM, Arribas-Blazquez M, Sanz-Rodriguez A, Concannon C, Olivos-Ore LA, Reschke CR, Mooney CM, Mooney C, Lugara E, Morgan J, Langa E, Jimenez-Pacheco A, Silva LF, Mesuret G, Boison D, Miras-Portugal MT, Letavic M, Artalejo AR, Bhattacharya A, Diaz-Hernandez M, Henshall DC, Engel T. Jimenez-Mateos EM, et al. Among authors: lugara e. Sci Rep. 2015 Dec 3;5:17486. doi: 10.1038/srep17486. Sci Rep. 2015. PMID: 26631939 Free PMC article.