Reproducibility, reliability and variability of FA and MD in the older healthy population: A test-retest multiparametric analysis

Pedro A Luque Laguna; Anna J E Combes; Johannes Streffer; Steven Einstein; Maarten Timmers; Steve C R Williams; Flavio Dell'Acqua

doi:10.1016/j.nicl.2020.102168

Reproducibility, reliability and variability of FA and MD in the older healthy population: A test-retest multiparametric analysis

Neuroimage Clin. 2020:26:102168. doi: 10.1016/j.nicl.2020.102168. Epub 2020 Jan 25.

Authors

Pedro A Luque Laguna¹, Anna J E Combes², Johannes Streffer³, Steven Einstein⁴, Maarten Timmers⁵, Steve C R Williams⁶, Flavio Dell'Acqua⁷

Affiliations

¹ Department 5 of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK; Natbrainlab, Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College, London, UK; Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology and Neuroscience, King's College, London, UK. Electronic address: pedro.luque.laguna@gmail.com.
² Department 5 of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK.
³ UCB Biopharma SPRL, Chemin du Foriest B-1420 Braine-l'Alleud, Belgium; Reference Center for Biological Markers of Dementia (BIODEM), Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
⁴ Janssen Research and Development LLC, Titusville, NJ, US; UCB Biopharma SPRL, Chemin du Foriest B-1420 Braine-l'Alleud, Belgium.
⁵ Janssen Research and Development, a division of Janssen Pharmaceutica NV, Beerse, Belgium; Reference Center for Biological Markers of Dementia (BIODEM), Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
⁶ Department 5 of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK. Electronic address: steve.williams@kcl.ac.uk.
⁷ Natbrainlab, Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College, London, UK; Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology and Neuroscience, King's College, London, UK. Electronic address: flavio.dellacqua@kcl.ac.uk.

Abstract

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In older healthy subjects, FA and MD show overall good test-retest reliability & reproducibility.
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MD is sistematically more reproducible than FA across the entire brain anatomy.
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FA is more reliable than MD in subcortical white matter regions.
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In high reliability & low reproducibility regions, variability between subjects is high and statistical power is low.
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In low reliability & high reproducibility regions, variability between subjects is low and statistical power is high.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Anisotropy
Brain / anatomy & histology*
Diffusion Tensor Imaging / methods*
Female
Humans
Image Processing, Computer-Assisted / methods*
Male
Middle Aged
Neuroimaging / methods*
Reproducibility of Results

Abstract

Publication types

MeSH terms

Grants and funding