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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1971 1
1980 1
1981 1
1983 1
1985 1
1987 2
1988 2
1990 2
1993 2
1994 1
1995 1
1996 2
1999 1
2000 1
2001 1
2002 1
2005 2
2007 1
2008 1
2010 4
2011 1
2012 2
2013 4
2014 1
2015 1
2016 3
2017 4
2018 5
2019 4
2020 5
2021 4
2022 3
2023 6
2024 3

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68 results

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Page 1
LSD1 inhibition: a therapeutic strategy in cancer?
Lynch JT, Harris WJ, Somervaille TC. Lynch JT, et al. Expert Opin Ther Targets. 2012 Dec;16(12):1239-49. doi: 10.1517/14728222.2012.722206. Epub 2012 Sep 8. Expert Opin Ther Targets. 2012. PMID: 22957941 Review.
Large-scale Pan-cancer Cell Line Screening Identifies Actionable and Effective Drug Combinations.
Bashi AC, Coker EA, Bulusu KC, Jaaks P, Crafter C, Lightfoot H, Milo M, McCarten K, Jenkins DF, van der Meer D, Lynch JT, Barthorpe S, Andersen CL, Barry ST, Beck A, Cidado J, Gordon JA, Hall C, Hall J, Mali I, Mironenko T, Mongeon K, Morris J, Richardson L, Smith PD, Tavana O, Tolley C, Thomas F, Willis BS, Yang W, O'Connor MJ, McDermott U, Critchlow SE, Drew L, Fawell SE, Mettetal JT, Garnett MJ. Bashi AC, et al. Among authors: lynch jt. Cancer Discov. 2024 Mar 8:OF1-OF20. doi: 10.1158/2159-8290.CD-23-0388. Online ahead of print. Cancer Discov. 2024. PMID: 38456804
AKT-mTORC1 reactivation is the dominant resistance driver for PI3Kβ/AKT inhibitors in PTEN-null breast cancer and can be overcome by combining with Mcl-1 inhibitors.
Dunn S, Eberlein C, Yu J, Gris-Oliver A, Ong SH, Yelland U, Cureton N, Staniszewska A, McEwen R, Fox M, Pilling J, Hopcroft P, Coker EA, Jaaks P, Garnett MJ, Isherwood B, Serra V, Davies BR, Barry ST, Lynch JT, Yusa K. Dunn S, et al. Among authors: lynch jt. Oncogene. 2022 Nov;41(46):5046-5060. doi: 10.1038/s41388-022-02482-9. Epub 2022 Oct 14. Oncogene. 2022. PMID: 36241868 Free PMC article.
Development of a Series of Pyrrolopyridone MAT2A Inhibitors.
Atkinson SJ, Bagal SK, Argyrou A, Askin S, Cheung T, Chiarparin E, Coen M, Collie IT, Dale IL, De Fusco C, Dillman K, Evans L, Feron LJ, Foster AJ, Grondine M, Kantae V, Lamont GM, Lamont S, Lynch JT, Nilsson Lill S, Robb GR, Saeh J, Schimpl M, Scott JS, Smith J, Srinivasan B, Tentarelli S, Vazquez-Chantada M, Wagner D, Walsh JJ, Watson D, Williamson B. Atkinson SJ, et al. Among authors: lynch jt. J Med Chem. 2024 Mar 28;67(6):4541-4559. doi: 10.1021/acs.jmedchem.3c01860. Epub 2024 Mar 11. J Med Chem. 2024. PMID: 38466661
LSD1 inhibitors disrupt the GFI1 transcription repressor complex.
Maiques-Diaz A, Lynch JT, Spencer GJ, Somervaille TCP. Maiques-Diaz A, et al. Among authors: lynch jt. Mol Cell Oncol. 2018 Aug 1;5(4):e1481813. doi: 10.1080/23723556.2018.1481813. eCollection 2018. Mol Cell Oncol. 2018. PMID: 30250927 Free PMC article.
68 results