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GLP-1R agonists demonstrate potential to treat Wolfram syndrome in human preclinical models.
Gorgogietas V, Rajaei B, Heeyoung C, Santacreu BJ, Marín-Cañas S, Salpea P, Sawatani T, Musuaya A, Arroyo MN, Moreno-Castro C, Benabdallah K, Demarez C, Toivonen S, Cosentino C, Pachera N, Lytrivi M, Cai Y, Carnel L, Brown C, Urano F, Marchetti P, Gilon P, Eizirik DL, Cnop M, Igoillo-Esteve M. Gorgogietas V, et al. Among authors: marin canas s. Diabetologia. 2023 Jul;66(7):1306-1321. doi: 10.1007/s00125-023-05905-8. Epub 2023 Mar 30. Diabetologia. 2023. PMID: 36995380 Free PMC article.
Interferons are key cytokines acting on pancreatic islets in type 1 diabetes.
Coomans de Brachène A, Alvelos MI, Szymczak F, Zimath PL, Castela A, Marmontel de Souza B, Roca Rivada A, Marín-Cañas S, Yi X, Op de Beeck A, Morgan NG, Sonntag S, Jawurek S, Title AC, Yesildag B, Pattou F, Kerr-Conte J, Montanya E, Nacher M, Marselli L, Marchetti P, Richardson SJ, Eizirik DL. Coomans de Brachène A, et al. Among authors: marin canas s. Diabetologia. 2024 May;67(5):908-927. doi: 10.1007/s00125-024-06106-7. Epub 2024 Feb 26. Diabetologia. 2024. PMID: 38409439
NR5A2/LRH-1 regulates the PTGS2-PGE2-PTGER1 pathway contributing to pancreatic islet survival and function.
Martin Vázquez E, Cobo-Vuilleumier N, Araujo Legido R, Marín-Cañas S, Nola E, Dorronsoro A, López Bermudo L, Crespo A, Romero-Zerbo SY, García-Fernández M, Martin Montalvo A, Rojas A, Comaills V, Bérmudez-Silva FJ, Gannon M, Martin F, Eizirik D, Lorenzo PI, Gauthier BR. Martin Vázquez E, et al. Among authors: marin canas s. iScience. 2022 May 2;25(5):104345. doi: 10.1016/j.isci.2022.104345. eCollection 2022 May 20. iScience. 2022. PMID: 35602948 Free PMC article.
DNAJC3 deficiency induces β-cell mitochondrial apoptosis and causes syndromic young-onset diabetes.
Lytrivi M, Senée V, Salpea P, Fantuzzi F, Philippi A, Abdulkarim B, Sawatani T, Marín-Cañas S, Pachera N, Degavre A, Singh P, Derbois C, Lechner D, Ladrière L, Igoillo-Esteve M, Cosentino C, Marselli L, Deleuze JF, Marchetti P, Eizirik DL, Nicolino M, Chaussenot A, Julier C, Cnop M. Lytrivi M, et al. Among authors: marin canas s. Eur J Endocrinol. 2021 Mar;184(3):455-468. doi: 10.1530/EJE-20-0636. Eur J Endocrinol. 2021. PMID: 33486469
A functional genomic approach to identify reference genes for human pancreatic beta cell real-time quantitative RT-PCR analysis.
Alvelos MI, Szymczak F, Castela Â, Marín-Cañas S, de Souza BM, Gkantounas I, Colli M, Fantuzzi F, Cosentino C, Igoillo-Esteve M, Marselli L, Marchetti P, Cnop M, Eizirik DL. Alvelos MI, et al. Among authors: marin canas s. Islets. 2021 Jul 4;13(3-4):51-65. doi: 10.1080/19382014.2021.1948282. Epub 2021 Jul 9. Islets. 2021. PMID: 34241569 Free PMC article.