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Dual IKZF2 and CK1α degrader targets acute myeloid leukemia cells.
Park SM, Miyamoto DK, Han GYQ, Chan M, Curnutt NM, Tran NL, Velleca A, Kim JH, Schurer A, Chang K, Xu W, Kharas MG, Woo CM. Park SM, et al. Among authors: miyamoto dk. Cancer Cell. 2023 Apr 10;41(4):726-739.e11. doi: 10.1016/j.ccell.2023.02.010. Epub 2023 Mar 9. Cancer Cell. 2023. PMID: 36898380 Free PMC article.
Design and Development of IKZF2 and CK1α Dual Degraders.
Miyamoto DK, Curnutt NM, Park SM, Stavropoulos A, Kharas MG, Woo CM. Miyamoto DK, et al. J Med Chem. 2023 Dec 28;66(24):16953-16979. doi: 10.1021/acs.jmedchem.3c01736. Epub 2023 Dec 12. J Med Chem. 2023. PMID: 38085607
Chemical genetics screening reveals KIAA1363 as a cytokine-lowering target.
Hunerdosse DM, Morris PJ, Miyamoto DK, Fisher KJ, Bateman LA, Ghazaleh JR, Zhong S, Nomura DK. Hunerdosse DM, et al. Among authors: miyamoto dk. ACS Chem Biol. 2014 Dec 19;9(12):2905-13. doi: 10.1021/cb500717g. Epub 2014 Nov 5. ACS Chem Biol. 2014. PMID: 25343321 Free PMC article.
GSTP1 Is a Driver of Triple-Negative Breast Cancer Cell Metabolism and Pathogenicity.
Louie SM, Grossman EA, Crawford LA, Ding L, Camarda R, Huffman TR, Miyamoto DK, Goga A, Weerapana E, Nomura DK. Louie SM, et al. Among authors: miyamoto dk. Cell Chem Biol. 2016 May 19;23(5):567-578. doi: 10.1016/j.chembiol.2016.03.017. Epub 2016 May 12. Cell Chem Biol. 2016. PMID: 27185638 Free PMC article.
Chemoproteomics-enabled covalent ligand screen reveals a cysteine hotspot in reticulon 4 that impairs ER morphology and cancer pathogenicity.
Bateman LA, Nguyen TB, Roberts AM, Miyamoto DK, Ku WM, Huffman TR, Petri Y, Heslin MJ, Contreras CM, Skibola CF, Olzmann JA, Nomura DK. Bateman LA, et al. Among authors: miyamoto dk. Chem Commun (Camb). 2017 Jun 29;53(53):7234-7237. doi: 10.1039/c7cc01480e. Chem Commun (Camb). 2017. PMID: 28352901 Free PMC article.