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CAR T-cell Entry into Tumor Islets Is a Two-Step Process Dependent on IFNγ and ICAM-1.
Kantari-Mimoun C, Barrin S, Vimeux L, Haghiri S, Gervais C, Joaquina S, Mittelstaet J, Mockel-Tenbrinck N, Kinkhabwala A, Damotte D, Lupo A, Sibony M, Alifano M, Dondi E, Bercovici N, Trautmann A, Kaiser AD, Donnadieu E. Kantari-Mimoun C, et al. Among authors: mockel tenbrinck n. Cancer Immunol Res. 2021 Dec;9(12):1425-1438. doi: 10.1158/2326-6066.CIR-20-0837. Epub 2021 Oct 22. Cancer Immunol Res. 2021. PMID: 34686489
T cells of colorectal cancer patients' stimulated by neoantigenic and cryptic peptides better recognize autologous tumor cells.
Schwarz S, Schmitz J, Löffler MW, Ghosh M, Rammensee HG, Olshvang E, Markel M, Mockel-Tenbrinck N, Dzionek A, Krake S, Arslan B, Kampe KD, Wendt A, Bauer P, Mullins CS, Schlosser A, Linnebacher M. Schwarz S, et al. Among authors: mockel tenbrinck n. J Immunother Cancer. 2022 Dec;10(12):e005651. doi: 10.1136/jitc-2022-005651. J Immunother Cancer. 2022. PMID: 36460334 Free PMC article.
A Notch/STAT3-driven Blimp-1/c-Maf-dependent molecular switch induces IL-10 expression in human CD4+ T cells and is defective in Crohn´s disease patients.
Ahlers J, Mantei A, Lozza L, Stäber M, Heinrich F, Bacher P, Hohnstein T, Menzel L, Yüz SG, Alvarez-Simon D, Bickenbach AR, Weidinger C, Mockel-Tenbrinck N, Kühl AA, Siegmund B, Maul J, Neumann C, Scheffold A. Ahlers J, et al. Among authors: mockel tenbrinck n. Mucosal Immunol. 2022 Mar;15(3):480-490. doi: 10.1038/s41385-022-00487-x. Epub 2022 Feb 15. Mucosal Immunol. 2022. PMID: 35169232 Free PMC article.
Automated manufacture of ΔNPM1 TCR-engineered T cells for AML therapy.
Yonezawa Ogusuku IE, Herbel V, Lennartz S, Brandes C, Argiro E, Fabian C, Hauck C, Hoogstraten C, Veld S, Hageman L, Teppert K, Koutsoumpli G, Griffioen M, Mockel-Tenbrinck N, Schaser T, de Groot R, Johnston ICD, Lock D. Yonezawa Ogusuku IE, et al. Among authors: mockel tenbrinck n. Mol Ther Methods Clin Dev. 2024 Feb 27;32(2):101224. doi: 10.1016/j.omtm.2024.101224. eCollection 2024 Jun 13. Mol Ther Methods Clin Dev. 2024. PMID: 38516690 Free PMC article.
Role of Blimp-1 in programing Th effector cells into IL-10 producers.
Neumann C, Heinrich F, Neumann K, Junghans V, Mashreghi MF, Ahlers J, Janke M, Rudolph C, Mockel-Tenbrinck N, Kühl AA, Heimesaat MM, Esser C, Im SH, Radbruch A, Rutz S, Scheffold A. Neumann C, et al. Among authors: mockel tenbrinck n. J Exp Med. 2014 Aug 25;211(9):1807-19. doi: 10.1084/jem.20131548. Epub 2014 Jul 29. J Exp Med. 2014. PMID: 25073792 Free PMC article.
Automated Enrichment, Transduction, and Expansion of Clinical-Scale CD62L+ T Cells for Manufacturing of Gene Therapy Medicinal Products.
Priesner C, Aleksandrova K, Esser R, Mockel-Tenbrinck N, Leise J, Drechsel K, Marburger M, Quaiser A, Goudeva L, Arseniev L, Kaiser AD, Glienke W, Koehl U. Priesner C, et al. Among authors: mockel tenbrinck n. Hum Gene Ther. 2016 Oct;27(10):860-869. doi: 10.1089/hum.2016.091. Hum Gene Ther. 2016. PMID: 27562135 Free PMC article.