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A TBK1 variant causes autophagolysosomal and motoneuron pathology without neuroinflammation in mice.
Brenner D, Sieverding K, Srinidhi J, Zellner S, Secker C, Yilmaz R, Dyckow J, Amr S, Ponomarenko A, Tunaboylu E, Douahem Y, Schlag JS, Rodríguez Martínez L, Kislinger G, Niemann C, Nalbach K, Ruf WP, Uhl J, Hollenbeck J, Schirmer L, Catanese A, Lobsiger CS, Danzer KM, Yilmazer-Hanke D, Münch C, Koch P, Freischmidt A, Fetting M, Behrends C, Parlato R, Weishaupt JH. Brenner D, et al. Among authors: nalbach k. J Exp Med. 2024 May 6;221(5):e20221190. doi: 10.1084/jem.20221190. Epub 2024 Mar 22. J Exp Med. 2024. PMID: 38517332 Free PMC article.
Lysosomal targeting of autophagosomes by the TECPR domain of TECPR2.
Fraiberg M, Tamim-Yecheskel BC, Kokabi K, Subic N, Heimer G, Eck F, Nalbach K, Behrends C, Ben-Zeev B, Shatz O, Elazar Z. Fraiberg M, et al. Among authors: nalbach k. Autophagy. 2021 Oct;17(10):3096-3108. doi: 10.1080/15548627.2020.1852727. Epub 2020 Nov 29. Autophagy. 2021. PMID: 33213269 Free PMC article.
LTK is an ER-resident receptor tyrosine kinase that regulates secretion.
Centonze FG, Reiterer V, Nalbach K, Saito K, Pawlowski K, Behrends C, Farhan H. Centonze FG, et al. Among authors: nalbach k. J Cell Biol. 2019 Aug 5;218(8):2470-2480. doi: 10.1083/jcb.201903068. Epub 2019 Jun 21. J Cell Biol. 2019. PMID: 31227593 Free PMC article.
Developing antisense oligonucleotides for a TECPR2 mutation-induced, ultra-rare neurological disorder using patient-derived cellular models.
Williams LA, Gerber DJ, Elder A, Tseng WC, Baru V, Delaney-Busch N, Ambrosi C, Mahimkar G, Joshi V, Shah H, Harikrishnan K, Upadhyay H, Rajendran SH, Dhandapani A, Meier J, Ryan SJ, Lewarch C, Black L, Douville J, Cinquino S, Legakis H, Nalbach K, Behrends C, Sato A, Galluzzi L, Yu TW, Brown D, Agrawal S, Margulies D, Kopin A, Dempsey GT. Williams LA, et al. Among authors: nalbach k. Mol Ther Nucleic Acids. 2022 Jun 22;29:189-203. doi: 10.1016/j.omtn.2022.06.015. eCollection 2022 Sep 13. Mol Ther Nucleic Acids. 2022. PMID: 35860385 Free PMC article.
Receptor-mediated endocytosis 8 (RME-8)/DNAJC13 is a novel positive modulator of autophagy and stabilizes cellular protein homeostasis.
Besemer AS, Maus J, Ax MDA, Stein A, Vo S, Freese C, Nalbach K, von Hilchen C, Pfalzgraf IF, Koziollek-Drechsler I, Silva B, Huesmann H, Boukhallouk F, Florin L, Kern A, Behl C, Clement AM. Besemer AS, et al. Among authors: nalbach k. Cell Mol Life Sci. 2021 Jan;78(2):645-660. doi: 10.1007/s00018-020-03521-y. Epub 2020 Apr 22. Cell Mol Life Sci. 2021. PMID: 32322926 Free PMC article.