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Page 1
Discovery and Optimization of Highly Selective Inhibitors of CDK5.
Daniels MH, Malojcic G, Clugston SL, Williams B, Coeffet-Le Gal M, Pan-Zhou XR, Venkatachalan S, Harmange JC, Ledeboer M. Daniels MH, et al. Among authors: pan zhou xr. J Med Chem. 2022 Feb 24;65(4):3575-3596. doi: 10.1021/acs.jmedchem.1c02069. Epub 2022 Feb 10. J Med Chem. 2022. PMID: 35143203
Transplanted organoids empower human preclinical assessment of drug candidate for the clinic.
Westerling-Bui AD, Fast EM, Soare TW, Venkatachalan S, DeRan M, Fanelli AB, Kyrychenko S, Hoang H, Corriea GM, Zhang W, Yu M, Daniels M, Malojcic G, Pan-Zhou XR, Ledeboer MW, Harmange JC, Emani M, Tibbitts TT, Reilly JF, Mundel P. Westerling-Bui AD, et al. Among authors: pan zhou xr. Sci Adv. 2022 Jul 8;8(27):eabj5633. doi: 10.1126/sciadv.abj5633. Epub 2022 Jul 6. Sci Adv. 2022. PMID: 35857479 Free PMC article.
Discovery of a Potent and Selective TRPC5 Inhibitor, Efficacious in a Focal Segmental Glomerulosclerosis Model.
Yu M, Ledeboer MW, Daniels M, Malojcic G, Tibbitts TT, Coeffet-Le Gal M, Pan-Zhou XR, Westerling-Bui A, Beconi M, Reilly JF, Mundel P, Harmange JC. Yu M, et al. Among authors: pan zhou xr. ACS Med Chem Lett. 2019 Oct 22;10(11):1579-1585. doi: 10.1021/acsmedchemlett.9b00430. eCollection 2019 Nov 14. ACS Med Chem Lett. 2019. PMID: 31749913 Free PMC article.
Safety and Efficacy of GFB-887, a TRPC5 Channel Inhibitor, in Patients With Focal Segmental Glomerulosclerosis, Treatment-Resistant Minimal Change Disease, or Diabetic Nephropathy: TRACTION-2 Trial Design.
Walsh L, Reilly JF, Cornwall C, Gaich GA, Gipson DS, Heerspink HJL, Johnson L, Trachtman H, Tuttle KR, Farag YMK, Padmanabhan K, Pan-Zhou XR, Woodworth JR, Czerwiec FS. Walsh L, et al. Among authors: pan zhou xr. Kidney Int Rep. 2021 Jul 23;6(10):2575-2584. doi: 10.1016/j.ekir.2021.07.006. eCollection 2021 Oct. Kidney Int Rep. 2021. PMID: 34622097 Free PMC article.
Pharmacokinetics of IDX184, a liver-targeted oral prodrug of 2'-methylguanosine-5'-monophosphate, in the monkey and formulation optimization for human exposure.
Pan-Zhou XR, Mayes BA, Rashidzadeh H, Gasparac R, Smith S, Bhadresa S, Gupta K, Cohen ML, Bu C, Good SS, Moussa A, Rush R. Pan-Zhou XR, et al. Eur J Drug Metab Pharmacokinet. 2016 Oct;41(5):567-74. doi: 10.1007/s13318-015-0267-4. Epub 2015 Apr 22. Eur J Drug Metab Pharmacokinet. 2016. PMID: 25898809 Clinical Trial.