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Page 1
Targeting the Aryl Hydrocarbon Receptor with Microbial Metabolite Mimics Alleviates Experimental Colitis in Mice.
Grycová A, Joo H, Maier V, Illés P, Vyhlídalová B, Poulíková K, Sládeková L, Nádvorník P, Vrzal R, Zemánková L, Pečinková P, Poruba M, Zapletalová I, Večeřa R, Anzenbacher P, Ehrmann J, Ondra P, Jung JW, Mani S, Dvořák Z. Grycová A, et al. Among authors: pecinkova p. J Med Chem. 2022 May 12;65(9):6859-6868. doi: 10.1021/acs.jmedchem.2c00208. Epub 2022 Apr 13. J Med Chem. 2022. PMID: 35416668
Deciphering structural bases of intestinal and hepatic selectivity in targeting pregnane X receptor with indole-based microbial mimics.
Li H, Illés P, Karunaratne CV, Nordstrøm LU, Luo X, Yang A, Qiu Y, Kurland IJ, Lukin DJ, Chen W, Jiskrová E, Krasulová K, Pečinková P, DesMarais VM, Liu Q, Albanese JM, Akki A, Longo M, Coffin B, Dou W, Mani S, Dvořák Z. Li H, et al. Among authors: pecinkova p. Bioorg Chem. 2021 Apr;109:104661. doi: 10.1016/j.bioorg.2021.104661. Epub 2021 Jan 22. Bioorg Chem. 2021. PMID: 33636438 Free PMC article.
In vitro safety signals for potential clinical development of the anti-inflammatory pregnane X receptor agonist FKK6.
Dvořák Z, Vyhlídalová B, Pečinková P, Li H, Anzenbacher P, Špičáková A, Anzenbacherová E, Chow V, Liu J, Krause H, Wilson D, Berés T, Tarkowski P, Chen D, Mani S. Dvořák Z, et al. Among authors: pecinkova p. Bioorg Chem. 2024 Mar;144:107137. doi: 10.1016/j.bioorg.2024.107137. Epub 2024 Jan 19. Bioorg Chem. 2024. PMID: 38245951
Gut Microbial Catabolites of Tryptophan Are Ligands and Agonists of the Aryl Hydrocarbon Receptor: A Detailed Characterization.
Vyhlídalová B, Krasulová K, Pečinková P, Marcalíková A, Vrzal R, Zemánková L, Vančo J, Trávníček Z, Vondráček J, Karasová M, Mani S, Dvořák Z. Vyhlídalová B, et al. Among authors: pecinkova p. Int J Mol Sci. 2020 Apr 9;21(7):2614. doi: 10.3390/ijms21072614. Int J Mol Sci. 2020. PMID: 32283770 Free PMC article.