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CaMKII as a Therapeutic Target in Cardiovascular Disease.
Reyes Gaido OE, Nkashama LJ, Schole KL, Wang Q, Umapathi P, Mesubi OO, Konstantinidis K, Luczak ED, Anderson ME. Reyes Gaido OE, et al. Annu Rev Pharmacol Toxicol. 2023 Jan 20;63:249-272. doi: 10.1146/annurev-pharmtox-051421-111814. Epub 2022 Aug 16. Annu Rev Pharmacol Toxicol. 2023. PMID: 35973713 Free article. Review.
Excessive O-GlcNAcylation Causes Heart Failure and Sudden Death.
Umapathi P, Mesubi OO, Banerjee PS, Abrol N, Wang Q, Luczak ED, Wu Y, Granger JM, Wei AC, Reyes Gaido OE, Florea L, Talbot CC Jr, Hart GW, Zachara NE, Anderson ME. Umapathi P, et al. Among authors: reyes gaido oe. Circulation. 2021 Apr 27;143(17):1687-1703. doi: 10.1161/CIRCULATIONAHA.120.051911. Epub 2021 Feb 17. Circulation. 2021. PMID: 33593071 Free PMC article.
An improved reporter identifies ruxolitinib as a potent and cardioprotective CaMKII inhibitor.
Reyes Gaido OE, Pavlaki N, Granger JM, Mesubi OO, Liu B, Lin BL, Long A, Walker D, Mayourian J, Schole KL, Terrillion CE, Nkashama LJ, Hulsurkar MM, Dorn LE, Ferrero KM, Huganir RL, Müller FU, Wehrens XHT, Liu JO, Luczak ED, Bezzerides VJ, Anderson ME. Reyes Gaido OE, et al. Sci Transl Med. 2023 Jun 21;15(701):eabq7839. doi: 10.1126/scitranslmed.abq7839. Epub 2023 Jun 21. Sci Transl Med. 2023. PMID: 37343080
Mitochondrial CaMKII causes adverse metabolic reprogramming and dilated cardiomyopathy.
Luczak ED, Wu Y, Granger JM, Joiner MA, Wilson NR, Gupta A, Umapathi P, Murphy KR, Reyes Gaido OE, Sabet A, Corradini E, Tseng WW, Wang Y, Heck AJR, Wei AC, Weiss RG, Anderson ME. Luczak ED, et al. Among authors: reyes gaido oe. Nat Commun. 2020 Sep 4;11(1):4416. doi: 10.1038/s41467-020-18165-6. Nat Commun. 2020. PMID: 32887881 Free PMC article.