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Methods to Activate the NLRP3 Inflammasome.
Saller BS, Neuwirt E, Groß O. Saller BS, et al. Methods Mol Biol. 2023;2696:169-197. doi: 10.1007/978-1-0716-3350-2_12. Methods Mol Biol. 2023. PMID: 37578723
NLRP3 as a sensor of metabolism gone awry.
Neuwirt E, Gorka O, Saller BS, Groß CJ, Madl T, Groß O. Neuwirt E, et al. Among authors: saller bs. Curr Opin Biotechnol. 2021 Apr;68:300-309. doi: 10.1016/j.copbio.2021.03.009. Epub 2021 Apr 13. Curr Opin Biotechnol. 2021. PMID: 33862489 Review.
Tyrosine kinase inhibitors can activate the NLRP3 inflammasome in myeloid cells through lysosomal damage and cell lysis.
Neuwirt E, Magnani G, Ćiković T, Wöhrle S, Fischer L, Kostina A, Flemming S, Fischenich NJ, Saller BS, Gorka O, Renner S, Agarinis C, Parker CN, Boettcher A, Farady CJ, Kesselring R, Berlin C, Backofen R, Rodriguez-Franco M, Kreutz C, Prinz M, Tholen M, Reinheckel T, Ott T, Groß CJ, Jost PJ, Groß O. Neuwirt E, et al. Among authors: saller bs. Sci Signal. 2023 Jan 17;16(768):eabh1083. doi: 10.1126/scisignal.abh1083. Epub 2023 Jan 17. Sci Signal. 2023. PMID: 36649377
Oncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activation.
Hamarsheh S, Osswald L, Saller BS, Unger S, De Feo D, Vinnakota JM, Konantz M, Uhl FM, Becker H, Lübbert M, Shoumariyeh K, Schürch C, Andrieux G, Venhoff N, Schmitt-Graeff A, Duquesne S, Pfeifer D, Cooper MA, Lengerke C, Boerries M, Duyster J, Niemeyer CM, Erlacher M, Blazar BR, Becher B, Groß O, Brummer T, Zeiser R. Hamarsheh S, et al. Among authors: saller bs. Nat Commun. 2020 Apr 3;11(1):1659. doi: 10.1038/s41467-020-15497-1. Nat Commun. 2020. PMID: 32246016 Free PMC article.
Pro- and anti-inflammatory macrophages express a sub-type specific purinergic receptor profile.
Merz J, Nettesheim A, von Garlen S, Albrecht P, Saller BS, Engelmann J, Hertle L, Schäfer I, Dimanski D, König S, Karnbrock L, Bulatova K, Peikert A, Hoppe N, Hilgendorf I, von Zur Mühlen C, Wolf D, Groß O, Bode C, Zirlik A, Stachon P. Merz J, et al. Among authors: saller bs. Purinergic Signal. 2021 Sep;17(3):481-492. doi: 10.1007/s11302-021-09798-3. Epub 2021 Jul 20. Purinergic Signal. 2021. PMID: 34282551 Free PMC article.
Strong xenoprotective function by single-copy transgenes placed sequentially at a permissive locus.
Rieblinger B, Fischer K, Kind A, Saller BS, Baars W, Schuster M, Wolf-van Buerck L, Schäffler A, Flisikowska T, Kurome M, Zakhartchenko V, Kessler B, Flisikowski K, Wolf E, Seissler J, Schwinzer R, Schnieke A. Rieblinger B, et al. Among authors: saller bs. Xenotransplantation. 2018 Mar;25(2):e12382. doi: 10.1111/xen.12382. Epub 2018 Jan 23. Xenotransplantation. 2018. PMID: 29359453
The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity.
Schneider KS, Groß CJ, Dreier RF, Saller BS, Mishra R, Gorka O, Heilig R, Meunier E, Dick MS, Ćiković T, Sodenkamp J, Médard G, Naumann R, Ruland J, Kuster B, Broz P, Groß O. Schneider KS, et al. Among authors: saller bs. Cell Rep. 2017 Dec 26;21(13):3846-3859. doi: 10.1016/j.celrep.2017.12.018. Cell Rep. 2017. PMID: 29281832 Free PMC article.