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Page 1
A simplified design for the C. elegans lifespan machine.
Abbott M, Banse SA, Melentijevic I, Jarrett CM, Ange JS, Sedore CA, Falkowski R, Blue BW, Coleman-Hulbert AL, Johnson E, Guo M, Lithgow GJ, Phillips PC, Driscoll M. Abbott M, et al. Among authors: sedore ca. J Biol Methods. 2020 Oct 26;7(4):e137. doi: 10.14440/jbm.2020.332. eCollection 2020. J Biol Methods. 2020. PMID: 33204740 Free PMC article.
Metformin treatment of diverse Caenorhabditis species reveals the importance of genetic background in longevity and healthspan extension outcomes.
Onken B, Sedore CA, Coleman-Hulbert AL, Hall D, Johnson E, Jones EG, Banse SA, Huynh P, Guo S, Xue J, Chen E, Harinath G, Foulger AC, Chao EA, Hope J, Bhaumik D, Plummer T, Inman D, Morshead M, Guo M, Lithgow GJ, Phillips PC, Driscoll M. Onken B, et al. Among authors: sedore ca. Aging Cell. 2022 Jan;21(1):e13488. doi: 10.1111/acel.13488. Epub 2021 Nov 27. Aging Cell. 2022. PMID: 34837316 Free PMC article.
Caenorhabditis Intervention Testing Program: the herbicide diuron does not robustly extend lifespan in nematodes.
Osman HC, Sedore CA, Jackson EG, Battistoni ET, Hall D, Foulger A, Lucanic M, Guo M, Driscoll M, Phillips P, Lithgow GJ. Osman HC, et al. Among authors: sedore ca. MicroPubl Biol. 2021 Sep 23;2021:10.17912/micropub.biology.000448. doi: 10.17912/micropub.biology.000448. eCollection 2021. MicroPubl Biol. 2021. PMID: 34585102 Free PMC article. No abstract available.
Caenorhabditis Intervention Testing Program: the creatine analog β-guanidinopropionic acid does not extend lifespan in nematodes.
Coleman-Hulbert AL, Johnson E, Sedore CA, Banse SA, Guo M, Driscoll M, Lithgow GJ, Phillips PC. Coleman-Hulbert AL, et al. Among authors: sedore ca. MicroPubl Biol. 2020;2020:10.17912/micropub.biology.000207. doi: 10.17912/micropub.biology.000207. Epub 2020 Jan 2. MicroPubl Biol. 2020. PMID: 31998863 Free PMC article. No abstract available.
Automated lifespan determination across Caenorhabditis strains and species reveals assay-specific effects of chemical interventions.
Banse SA, Lucanic M, Sedore CA, Coleman-Hulbert AL, Plummer WT, Chen E, Kish JL, Hall D, Onken B, Presley MP, Jones EG, Blue BW, Garrett T, Abbott M, Xue J, Guo S, Johnson E, Foulger AC, Chamoli M, Falkowski R, Melentijevic I, Harinath G, Huynh P, Patel S, Edgar D, Jarrett CM, Guo M, Kapahi P, Lithgow GJ, Driscoll M, Phillips PC. Banse SA, et al. Among authors: sedore ca. Geroscience. 2019 Dec;41(6):945-960. doi: 10.1007/s11357-019-00108-9. Epub 2019 Dec 10. Geroscience. 2019. PMID: 31820364 Free PMC article.
The coupling between healthspan and lifespan in Caenorhabditis depends on complex interactions between compound intervention and genetic background.
Banse SA, Jackson EG, Sedore CA, Onken B, Hall D, Coleman-Hulbert A, Huynh P, Garrett T, Johnson E, Harinath G, Inman D, Guo S, Morshead M, Xue J, Falkowski R, Chen E, Herrera C, Kirsch AJ, Perez VI, Guo M, Lithgow GJ, Driscoll M, Phillips PC. Banse SA, et al. Among authors: sedore ca. Aging (Albany NY). 2024 Apr 12;16(7):5829-5855. doi: 10.18632/aging.205743. Epub 2024 Apr 12. Aging (Albany NY). 2024. PMID: 38613792 Free PMC article.
Caenorhabditis Intervention Testing Program: the tyrosine kinase inhibitor imatinib mesylate does not extend lifespan in nematodes.
Coleman-Hulbert AL, Johnson E, Sedore CA, Banse SA, Guo M, Driscoll M, Lithgow GJ, Phillips PC. Coleman-Hulbert AL, et al. Among authors: sedore ca. MicroPubl Biol. 2019;2019:10.17912/micropub.biology.000131. doi: 10.17912/micropub.biology.000131. Epub 2019 Jul 3. MicroPubl Biol. 2019. PMID: 32010883 Free PMC article. No abstract available.
Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects.
Lucanic M, Plummer WT, Chen E, Harke J, Foulger AC, Onken B, Coleman-Hulbert AL, Dumas KJ, Guo S, Johnson E, Bhaumik D, Xue J, Crist AB, Presley MP, Harinath G, Sedore CA, Chamoli M, Kamat S, Chen MK, Angeli S, Chang C, Willis JH, Edgar D, Royal MA, Chao EA, Patel S, Garrett T, Ibanez-Ventoso C, Hope J, Kish JL, Guo M, Lithgow GJ, Driscoll M, Phillips PC. Lucanic M, et al. Among authors: sedore ca. Nat Commun. 2017 Feb 21;8:14256. doi: 10.1038/ncomms14256. Nat Commun. 2017. PMID: 28220799 Free PMC article.
Caenorhabditis Intervention Testing Program: the farnesoid X receptor agonist obeticholic acid does not robustly extend lifespan in nematodes.
Morshead ML, Sedore CA, Jones EG, Hall D, Plummer WT, Garrett T, Lucanic M, Guo M, Driscoll M, Phillips PC, Lithgow G. Morshead ML, et al. Among authors: sedore ca. MicroPubl Biol. 2020 May 27;2020:10.17912/micropub.biology.000257. doi: 10.17912/micropub.biology.000257. MicroPubl Biol. 2020. PMID: 32550518 Free PMC article. No abstract available.
Antioxidants green tea extract and nordihydroguaiaretic acid confer species and strain-specific lifespan and health effects in Caenorhabditis nematodes.
Banse SA, Sedore CA, Johnson E, Coleman-Hulbert AL, Onken B, Hall D, Jackson EG, Huynh P, Foulger AC, Guo S, Garrett T, Xue J, Inman D, Morshead ML, Plummer WT, Chen E, Bhaumik D, Chen MK, Harinath G, Chamoli M, Quinn RP, Falkowski R, Edgar D, Schmidt MO, Lucanic M, Guo M, Driscoll M, Lithgow GJ, Phillips PC. Banse SA, et al. Among authors: sedore ca. Geroscience. 2024 Apr;46(2):2239-2251. doi: 10.1007/s11357-023-00978-0. Epub 2023 Nov 4. Geroscience. 2024. PMID: 37923874 Free PMC article.