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Structure, mechanism, and inhibition of Hedgehog acyltransferase.
Coupland CE, Andrei SA, Ansell TB, Carrique L, Kumar P, Sefer L, Schwab RA, Byrne EFX, Pardon E, Steyaert J, Magee AI, Lanyon-Hogg T, Sansom MSP, Tate EW, Siebold C. Coupland CE, et al. Among authors: sefer l. Mol Cell. 2021 Dec 16;81(24):5025-5038.e10. doi: 10.1016/j.molcel.2021.11.018. Epub 2021 Dec 9. Mol Cell. 2021. PMID: 34890564 Free PMC article.
Design, Synthesis, and Evaluation of Inhibitors of Hedgehog Acyltransferase.
Ritzefeld M, Zhang L, Xiao Z, Andrei SA, Boyd O, Masumoto N, Rodgers UR, Artelsmair M, Sefer L, Hayes A, Gavriil ES, Raynaud FI, Burke R, Blagg J, Rzepa HS, Siebold C, Magee AI, Lanyon-Hogg T, Tate EW. Ritzefeld M, et al. Among authors: sefer l. J Med Chem. 2024 Jan 25;67(2):1061-1078. doi: 10.1021/acs.jmedchem.3c01363. Epub 2024 Jan 10. J Med Chem. 2024. PMID: 38198226 Free PMC article.
Photochemical Probe Identification of a Small-Molecule Inhibitor Binding Site in Hedgehog Acyltransferase (HHAT)*.
Lanyon-Hogg T, Ritzefeld M, Zhang L, Andrei SA, Pogranyi B, Mondal M, Sefer L, Johnston CD, Coupland CE, Greenfield JL, Newington J, Fuchter MJ, Magee AI, Siebold C, Tate EW. Lanyon-Hogg T, et al. Among authors: sefer l. Angew Chem Int Ed Engl. 2021 Jun 7;60(24):13542-13547. doi: 10.1002/anie.202014457. Epub 2021 May 14. Angew Chem Int Ed Engl. 2021. PMID: 33768725 Free PMC article.
Photochemical Probe Identification of a Small-Molecule Inhibitor Binding Site in Hedgehog Acyltransferase (HHAT).
Lanyon-Hogg T, Ritzefeld M, Zhang L, Andrei SA, Pogranyi B, Mondal M, Sefer L, Johnston CD, Coupland CE, Greenfield JL, Newington J, Fuchter MJ, Magee AI, Siebold C, Tate EW. Lanyon-Hogg T, et al. Among authors: sefer l. Angew Chem Weinheim Bergstr Ger. 2021 Jun 7;133(24):13654-13659. doi: 10.1002/ange.202014457. Epub 2021 May 14. Angew Chem Weinheim Bergstr Ger. 2021. PMID: 38504937 Free PMC article.
Electrostatically-guided inhibition of Curli amyloid nucleation by the CsgC-like family of chaperones.
Taylor JD, Hawthorne WJ, Lo J, Dear A, Jain N, Meisl G, Andreasen M, Fletcher C, Koch M, Darvill N, Scull N, Escalera-Maurer A, Sefer L, Wenman R, Lambert S, Jean J, Xu Y, Turner B, Kazarian SG, Chapman MR, Bubeck D, de Simone A, Knowles TP, Matthews SJ. Taylor JD, et al. Among authors: sefer l. Sci Rep. 2016 Apr 21;6:24656. doi: 10.1038/srep24656. Sci Rep. 2016. PMID: 27098162 Free PMC article.