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p53 convergently activates Dux/DUX4 in embryonic stem cells and in facioscapulohumeral muscular dystrophy cell models.
Grow EJ, Weaver BD, Smith CM, Guo J, Stein P, Shadle SC, Hendrickson PG, Johnson NE, Butterfield RJ, Menafra R, Kloet SL, van der Maarel SM, Williams CJ, Cairns BR. Grow EJ, et al. Among authors: shadle sc. Nat Genet. 2021 Aug;53(8):1207-1220. doi: 10.1038/s41588-021-00893-0. Epub 2021 Jul 15. Nat Genet. 2021. PMID: 34267371 Free PMC article.
BET bromodomain inhibitors and agonists of the beta-2 adrenergic receptor identified in screens for compounds that inhibit DUX4 expression in FSHD muscle cells.
Campbell AE, Oliva J, Yates MP, Zhong JW, Shadle SC, Snider L, Singh N, Tai S, Hiramuki Y, Tawil R, van der Maarel SM, Tapscott SJ, Sverdrup FM. Campbell AE, et al. Among authors: shadle sc. Skelet Muscle. 2017 Sep 4;7(1):16. doi: 10.1186/s13395-017-0134-x. Skelet Muscle. 2017. PMID: 28870238 Free PMC article.