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A drug-like molecule engages nuclear hormone receptor DAF-12/FXR to regulate mitophagy and extend lifespan.
Nat Aging. 2023 Dec;3(12):1529-1543. doi: 10.1038/s43587-023-00524-9. Epub 2023 Nov 13.
Nat Aging. 2023.
PMID: 37957360
Free PMC article.
The mitochondrial permeability transition pore activates the mitochondrial unfolded protein response and promotes aging.
Angeli S, Foulger A, Chamoli M, Peiris TH, Gerencser A, Shahmirzadi AA, Andersen J, Lithgow G.
Angeli S, et al. Among authors: shahmirzadi aa.
Elife. 2021 Sep 1;10:e63453. doi: 10.7554/eLife.63453.
Elife. 2021.
PMID: 34467850
Free PMC article.
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