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Inhibition of a signaling modality within the gp130 receptor enhances tissue regeneration and mitigates osteoarthritis.
Shkhyan R, Flynn C, Lamoure E, Sarkar A, Van Handel B, Li J, York J, Banks N, Van der Horst R, Liu NQ, Lee S, Bajaj P, Vadivel K, Harn HI, Tassey J, Lozito T, Lieberman JR, Chuong CM, Hurtig MS, Evseenko D. Shkhyan R, et al. Sci Transl Med. 2023 Mar 22;15(688):eabq2395. doi: 10.1126/scitranslmed.abq2395. Epub 2023 Mar 22. Sci Transl Med. 2023. PMID: 36947594 Free PMC article.
STAT3 promotes a youthful epigenetic state in articular chondrocytes.
Sarkar A, Liu NQ, Magallanes J, Tassey J, Lee S, Shkhyan R, Lee Y, Lu J, Ouyang Y, Tang H, Bian F, Tao L, Segil N, Ernst J, Lyons K, Horvath S, Evseenko D. Sarkar A, et al. Among authors: shkhyan r. Aging Cell. 2023 Feb;22(2):e13773. doi: 10.1111/acel.13773. Epub 2023 Jan 13. Aging Cell. 2023. PMID: 36638270 Free PMC article.
gp130/STAT3 signaling is required for homeostatic proliferation and anabolism in postnatal growth plate and articular chondrocytes.
Liu NQ, Lin Y, Li L, Lu J, Geng D, Zhang J, Jashashvili T, Buser Z, Magallanes J, Tassey J, Shkhyan R, Sarkar A, Lopez N, Lee S, Lee Y, Wang L, Petrigliano FA, Van Handel B, Lyons K, Evseenko D. Liu NQ, et al. Among authors: shkhyan r. Commun Biol. 2022 Jan 17;5(1):64. doi: 10.1038/s42003-021-02944-y. Commun Biol. 2022. PMID: 35039652 Free PMC article.
Modulation of Hedgehog Signaling by Kappa Opioids to Attenuate Osteoarthritis.
Weber AE, Jalali O, Limfat S, Shkhyan R, Van Der Horst R, Lee S, Lin Y, Li L, Mayer EN, Wang L, Liu NQ, Petrigliano FA, Lieberman JR, Evseenko D. Weber AE, et al. Among authors: shkhyan r. Arthritis Rheumatol. 2020 Aug;72(8):1278-1288. doi: 10.1002/art.41250. Epub 2020 Jun 24. Arthritis Rheumatol. 2020. PMID: 32249508 Free PMC article.
Long-term repair of porcine articular cartilage using cryopreservable, clinically compatible human embryonic stem cell-derived chondrocytes.
Petrigliano FA, Liu NQ, Lee S, Tassey J, Sarkar A, Lin Y, Li L, Yu Y, Geng D, Zhang J, Shkhyan R, Bogdanov J, Van Handel B, Ferguson GB, Lee Y, Hinderer S, Tseng KC, Kavanaugh A, Crump JG, Pyle AD, Schenke-Layland K, Billi F, Wang L, Lieberman J, Hurtig M, Evseenko D. Petrigliano FA, et al. Among authors: shkhyan r. NPJ Regen Med. 2021 Nov 23;6(1):77. doi: 10.1038/s41536-021-00187-3. NPJ Regen Med. 2021. PMID: 34815400 Free PMC article.
Drug-induced modulation of gp130 signalling prevents articular cartilage degeneration and promotes repair.
Shkhyan R, Van Handel B, Bogdanov J, Lee S, Yu Y, Scheinberg M, Banks NW, Limfat S, Chernostrik A, Franciozi CE, Alam MP, John V, Wu L, Ferguson GB, Nsair A, Petrigliano FA, Vangsness CT, Vadivel K, Bajaj P, Wang L, Liu NQ, Evseenko D. Shkhyan R, et al. Ann Rheum Dis. 2018 May;77(5):760-769. doi: 10.1136/annrheumdis-2017-212037. Epub 2018 Feb 7. Ann Rheum Dis. 2018. PMID: 29436471 Free PMC article.
Author Correction: gp130/STAT3 signaling is required for homeostatic proliferation and anabolism in postnatal growth plate and articular chondrocytes.
Liu NQ, Lin Y, Li L, Lu J, Geng D, Zhang J, Jashashvili T, Buser Z, Magallanes J, Tassey J, Shkhyan R, Sarkar A, Lopez N, Lee S, Lee Y, Wang L, Petrigliano FA, Van Handel B, Lyons K, Evseenko D. Liu NQ, et al. Among authors: shkhyan r. Commun Biol. 2022 Feb 25;5(1):200. doi: 10.1038/s42003-022-03167-5. Commun Biol. 2022. PMID: 35217719 Free PMC article. No abstract available.
Mapping molecular landmarks of human skeletal ontogeny and pluripotent stem cell-derived articular chondrocytes.
Ferguson GB, Van Handel B, Bay M, Fiziev P, Org T, Lee S, Shkhyan R, Banks NW, Scheinberg M, Wu L, Saitta B, Elphingstone J, Larson AN, Riester SM, Pyle AD, Bernthal NM, Mikkola HK, Ernst J, van Wijnen AJ, Bonaguidi M, Evseenko D. Ferguson GB, et al. Among authors: shkhyan r. Nat Commun. 2018 Sep 7;9(1):3634. doi: 10.1038/s41467-018-05573-y. Nat Commun. 2018. PMID: 30194383 Free PMC article.
13 results