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Page 1
Transposon-associated TnpB is a programmable RNA-guided DNA endonuclease.
Karvelis T, Druteika G, Bigelyte G, Budre K, Zedaveinyte R, Silanskas A, Kazlauskas D, Venclovas Č, Siksnys V. Karvelis T, et al. Among authors: silanskas a. Nature. 2021 Nov;599(7886):692-696. doi: 10.1038/s41586-021-04058-1. Epub 2021 Oct 7. Nature. 2021. PMID: 34619744 Free PMC article.
TnpB structure reveals minimal functional core of Cas12 nuclease family.
Sasnauskas G, Tamulaitiene G, Druteika G, Carabias A, Silanskas A, Kazlauskas D, Venclovas Č, Montoya G, Karvelis T, Siksnys V. Sasnauskas G, et al. Among authors: silanskas a. Nature. 2023 Apr;616(7956):384-389. doi: 10.1038/s41586-023-05826-x. Epub 2023 Apr 5. Nature. 2023. PMID: 37020015
Miniature type V-F CRISPR-Cas nucleases enable targeted DNA modification in cells.
Bigelyte G, Young JK, Karvelis T, Budre K, Zedaveinyte R, Djukanovic V, Van Ginkel E, Paulraj S, Gasior S, Jones S, Feigenbutz L, Clair GS, Barone P, Bohn J, Acharya A, Zastrow-Hayes G, Henkel-Heinecke S, Silanskas A, Seidel R, Siksnys V. Bigelyte G, et al. Among authors: silanskas a. Nat Commun. 2021 Oct 26;12(1):6191. doi: 10.1038/s41467-021-26469-4. Nat Commun. 2021. PMID: 34702830 Free PMC article.
Short prokaryotic Argonautes provide defence against incoming mobile genetic elements through NAD+ depletion.
Zaremba M, Dakineviciene D, Golovinas E, Zagorskaitė E, Stankunas E, Lopatina A, Sorek R, Manakova E, Ruksenaite A, Silanskas A, Asmontas S, Grybauskas A, Tylenyte U, Jurgelaitis E, Grigaitis R, Timinskas K, Venclovas Č, Siksnys V. Zaremba M, et al. Among authors: silanskas a. Nat Microbiol. 2022 Nov;7(11):1857-1869. doi: 10.1038/s41564-022-01239-0. Epub 2022 Oct 3. Nat Microbiol. 2022. PMID: 36192537
Activation of Thoeris antiviral system via SIR2 effector filament assembly.
Tamulaitiene G, Sabonis D, Sasnauskas G, Ruksenaite A, Silanskas A, Avraham C, Ofir G, Sorek R, Zaremba M, Siksnys V. Tamulaitiene G, et al. Among authors: silanskas a. Nature. 2024 Mar;627(8003):431-436. doi: 10.1038/s41586-024-07092-x. Epub 2024 Feb 21. Nature. 2024. PMID: 38383786
smFRET Detection of Cis and Trans DNA Interactions by the BfiI Restriction Endonuclease.
Ivanovaitė ŠN, Paksaitė J, Kopu Stas A, Karzaitė G, Rutkauskas D, Silanskas A, Sasnauskas G, Zaremba M, Jones SK Jr, Tutkus M. Ivanovaitė ŠN, et al. Among authors: silanskas a. J Phys Chem B. 2023 Jul 27;127(29):6470-6478. doi: 10.1021/acs.jpcb.3c03269. Epub 2023 Jul 15. J Phys Chem B. 2023. PMID: 37452775 Free PMC article.
21 results