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Discovery of senolytics using machine learning.
Smer-Barreto V, Quintanilla A, Elliott RJR, Dawson JC, Sun J, Campa VM, Lorente-Macías Á, Unciti-Broceta A, Carragher NO, Acosta JC, Oyarzún DA. Smer-Barreto V, et al. Nat Commun. 2023 Jun 10;14(1):3445. doi: 10.1038/s41467-023-39120-1. Nat Commun. 2023. PMID: 37301862 Free PMC article.
Cytoplasmic innate immune sensing by the caspase-4 non-canonical inflammasome promotes cellular senescence.
Fernández-Duran I, Quintanilla A, Tarrats N, Birch J, Hari P, Millar FR, Lagnado AB, Smer-Barreto V, Muir M, Brunton VG, Passos JF, Acosta JC. Fernández-Duran I, et al. Among authors: smer barreto v. Cell Death Differ. 2022 Jun;29(6):1267-1282. doi: 10.1038/s41418-021-00917-6. Epub 2021 Dec 16. Cell Death Differ. 2022. PMID: 34916628 Free PMC article.