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Early Alzheimer's disease pathology in human cortex involves transient cell states.
Gazestani V, Kamath T, Nadaf NM, Dougalis A, Burris SJ, Rooney B, Junkkari A, Vanderburg C, Pelkonen A, Gomez-Budia M, Välimäki NN, Rauramaa T, Therrien M, Koivisto AM, Tegtmeyer M, Herukka SK, Abdulraouf A, Marsh SE, Hiltunen M, Nehme R, Malm T, Stevens B, Leinonen V, Macosko EZ. Gazestani V, et al. Among authors: tegtmeyer m. Cell. 2023 Sep 28;186(20):4438-4453.e23. doi: 10.1016/j.cell.2023.08.005. Cell. 2023. PMID: 37774681
Natural variation in gene expression and viral susceptibility revealed by neural progenitor cell villages.
Wells MF, Nemesh J, Ghosh S, Mitchell JM, Salick MR, Mello CJ, Meyer D, Pietilainen O, Piccioni F, Guss EJ, Raghunathan K, Tegtmeyer M, Hawes D, Neumann A, Worringer KA, Ho D, Kommineni S, Chan K, Peterson BK, Raymond JJ, Gold JT, Siekmann MT, Zuccaro E, Nehme R, Kaykas A, Eggan K, McCarroll SA. Wells MF, et al. Among authors: tegtmeyer m. Cell Stem Cell. 2023 Mar 2;30(3):312-332.e13. doi: 10.1016/j.stem.2023.01.010. Epub 2023 Feb 15. Cell Stem Cell. 2023. PMID: 36796362 Free PMC article.
The 22q11.2 region regulates presynaptic gene-products linked to schizophrenia.
Nehme R, Pietiläinen O, Artomov M, Tegtmeyer M, Valakh V, Lehtonen L, Bell C, Singh T, Trehan A, Sherwood J, Manning D, Peirent E, Malik R, Guss EJ, Hawes D, Beccard A, Bara AM, Hazelbaker DZ, Zuccaro E, Genovese G, Loboda AA, Neumann A, Lilliehook C, Kuismin O, Hamalainen E, Kurki M, Hultman CM, Kähler AK, Paulo JA, Ganna A, Madison J, Cohen B, McPhie D, Adolfsson R, Perlis R, Dolmetsch R, Farhi S, McCarroll S, Hyman S, Neale B, Barrett LE, Harper W, Palotie A, Daly M, Eggan K. Nehme R, et al. Among authors: tegtmeyer m. Nat Commun. 2022 Jun 27;13(1):3690. doi: 10.1038/s41467-022-31436-8. Nat Commun. 2022. PMID: 35760976 Free PMC article.
Small-molecule screen reveals pathways that regulate C4 secretion in stem cell-derived astrocytes.
Rapino F, Natoli T, Limone F, O'Connor E, Blank J, Tegtmeyer M, Chen W, Norabuena E, Narula J, Hazelbaker D, Angelini G, Barrett L, O'Neil A, Beattie UK, Thanos JM, de Rivera H, Sheridan SD, Perlis RH, McCarroll SA, Stevens B, Subramanian A, Nehme R, Rubin LL. Rapino F, et al. Among authors: tegtmeyer m. Stem Cell Reports. 2023 Jan 10;18(1):237-253. doi: 10.1016/j.stemcr.2022.11.018. Epub 2022 Dec 22. Stem Cell Reports. 2023. PMID: 36563689 Free PMC article.
Robust induction of functional astrocytes using NGN2 expression in human pluripotent stem cells.
Berryer MH, Tegtmeyer M, Binan L, Valakh V, Nathanson A, Trendafilova D, Crouse E, Klein JA, Meyer D, Pietiläinen O, Rapino F, Farhi SL, Rubin LL, McCarroll SA, Nehme R, Barrett LE. Berryer MH, et al. Among authors: tegtmeyer m. iScience. 2023 May 30;26(7):106995. doi: 10.1016/j.isci.2023.106995. eCollection 2023 Jul 21. iScience. 2023. PMID: 37534135 Free PMC article.
High-dimensional phenotyping to define the genetic basis of cellular morphology.
Tegtmeyer M, Arora J, Asgari S, Cimini BA, Nadig A, Peirent E, Liyanage D, Way GP, Weisbart E, Nathan A, Amariuta T, Eggan K, Haghighi M, McCarroll SA, O'Connor L, Carpenter AE, Singh S, Nehme R, Raychaudhuri S. Tegtmeyer M, et al. Nat Commun. 2024 Jan 6;15(1):347. doi: 10.1038/s41467-023-44045-w. Nat Commun. 2024. PMID: 38184653 Free PMC article.
Early Alzheimer's disease pathology in human cortex is associated with a transient phase of distinct cell states.
Gazestani V, Kamath T, Nadaf NM, Burris SJ, Rooney B, Junkkari A, Vanderburg C, Rauramaa T, Therrien M, Tegtmeyer M, Herukka SK, Abdulraouf A, Marsh S, Malm T, Hiltunen M, Nehme R, Stevens B, Leinonen V, Macosko EZ. Gazestani V, et al. Among authors: tegtmeyer m. bioRxiv [Preprint]. 2023 Jun 5:2023.06.03.543569. doi: 10.1101/2023.06.03.543569. bioRxiv. 2023. PMID: 37333365 Free PMC article. Updated. Preprint.
13 results