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Fibrocytes boost tumor-supportive phenotypic switches in the lung cancer niche via the endothelin system.
Weigert A, Zheng X, Nenzel A, Turkowski K, Günther S, Strack E, Sirait-Fischer E, Elwakeel E, Kur IM, Nikam VS, Valasarajan C, Winter H, Wissgott A, Voswinkel R, Grimminger F, Brüne B, Seeger W, Pullamsetti SS, Savai R. Weigert A, et al. Among authors: valasarajan c. Nat Commun. 2022 Oct 14;13(1):6078. doi: 10.1038/s41467-022-33458-8. Nat Commun. 2022. PMID: 36241617 Free PMC article.
Epigenetic reactivation of transcriptional programs orchestrating fetal lung development in human pulmonary hypertension.
Chelladurai P, Kuenne C, Bourgeois A, Günther S, Valasarajan C, Cherian AV, Rottier RJ, Romanet C, Weigert A, Boucherat O, Eichstaedt CA, Ruppert C, Guenther A, Braun T, Looso M, Savai R, Seeger W, Bauer UM, Bonnet S, Pullamsetti SS. Chelladurai P, et al. Among authors: valasarajan c. Sci Transl Med. 2022 Jun 8;14(648):eabe5407. doi: 10.1126/scitranslmed.abe5407. Epub 2022 Jun 8. Sci Transl Med. 2022. PMID: 35675437
HIF1α-AS1 is a DNA:DNA:RNA triplex-forming lncRNA interacting with the HUSH complex.
Leisegang MS, Bains JK, Seredinski S, Oo JA, Krause NM, Kuo CC, Günther S, Sentürk Cetin N, Warwick T, Cao C, Boos F, Izquierdo Ponce J, Haydar S, Bednarz R, Valasarajan C, Fuhrmann DC, Preussner J, Looso M, Pullamsetti SS, Schulz MH, Jonker HRA, Richter C, Rezende F, Gilsbach R, Pflüger-Müller B, Wittig I, Grummt I, Ribarska T, Costa IG, Schwalbe H, Brandes RP. Leisegang MS, et al. Among authors: valasarajan c. Nat Commun. 2022 Nov 2;13(1):6563. doi: 10.1038/s41467-022-34252-2. Nat Commun. 2022. PMID: 36323673 Free PMC article.
A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension.
Dabral S, Muecke C, Valasarajan C, Schmoranzer M, Wietelmann A, Semenza GL, Meister M, Muley T, Seeger-Nukpezah T, Samakovlis C, Weissmann N, Grimminger F, Seeger W, Savai R, Pullamsetti SS. Dabral S, et al. Among authors: valasarajan c. Nat Commun. 2019 May 13;10(1):2130. doi: 10.1038/s41467-019-10044-z. Nat Commun. 2019. PMID: 31086178 Free PMC article.
Long Noncoding RNA MANTIS Facilitates Endothelial Angiogenic Function.
Leisegang MS, Fork C, Josipovic I, Richter FM, Preussner J, Hu J, Miller MJ, Epah J, Hofmann P, Günther S, Moll F, Valasarajan C, Heidler J, Ponomareva Y, Freiman TM, Maegdefessel L, Plate KH, Mittelbronn M, Uchida S, Künne C, Stellos K, Schermuly RT, Weissmann N, Devraj K, Wittig I, Boon RA, Dimmeler S, Pullamsetti SS, Looso M, Miller FJ Jr, Brandes RP. Leisegang MS, et al. Among authors: valasarajan c. Circulation. 2017 Jul 4;136(1):65-79. doi: 10.1161/CIRCULATIONAHA.116.026991. Epub 2017 Mar 28. Circulation. 2017. PMID: 28351900 Free PMC article.
Long Noncoding RNA TYKRIL Plays a Role in Pulmonary Hypertension via the p53-mediated Regulation of PDGFRβ.
Zehendner CM, Valasarajan C, Werner A, Boeckel JN, Bischoff FC, John D, Weirick T, Glaser SF, Rossbach O, Jaé N, Demolli S, Khassafi F, Yuan K, de Jesus Perez VA, Michalik KM, Chen W, Seeger W, Guenther A, Wasnick RM, Uchida S, Zeiher AM, Dimmeler S, Pullamsetti SS. Zehendner CM, et al. Among authors: valasarajan c. Am J Respir Crit Care Med. 2020 Nov 15;202(10):1445-1457. doi: 10.1164/rccm.201910-2041OC. Am J Respir Crit Care Med. 2020. PMID: 32634060 Free PMC article.