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Preclinical evaluation of [111 In]MICA-401, an activity-based probe for SPECT imaging of in vivo uPA activity.
Vangestel C, Thomae D, Van Soom J, Ides J, Wyffels L, Pauwels P, Stroobants S, Van der Veken P, Magdolen V, Joossens J, Augustyns K, Staelens S. Vangestel C, et al. Among authors: van soom j. Contrast Media Mol Imaging. 2016 Nov;11(6):448-458. doi: 10.1002/cmmi.1706. Epub 2016 Aug 24. Contrast Media Mol Imaging. 2016. PMID: 27558262 Free article.
Decreased levels of active uPA and KLK8 assessed by [111 In]MICA-401 binding correlate with the seizure burden in an animal model of temporal lobe epilepsy.
Missault S, Peeters L, Amhaoul H, Thomae D, Van Eetveldt A, Favier B, Thakur A, Van Soom J, Pitkänen A, Augustyns K, Joossens J, Staelens S, Dedeurwaerdere S. Missault S, et al. Among authors: van soom j. Epilepsia. 2017 Sep;58(9):1615-1625. doi: 10.1111/epi.13845. Epub 2017 Jul 19. Epilepsia. 2017. PMID: 28722103