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Enhanced tyrosine hydroxylase activity induces oxidative stress, causes accumulation of autotoxic catecholamine metabolites, and augments amphetamine effects in vivo.
Vecchio LM, Sullivan P, Dunn AR, Bermejo MK, Fu R, Masoud ST, Gregersen E, Urs NM, Nazari R, Jensen PH, Ramsey A, Goldstein DS, Miller GW, Salahpour A. Vecchio LM, et al. J Neurochem. 2021 Aug;158(4):960-979. doi: 10.1111/jnc.15432. Epub 2021 Jun 12. J Neurochem. 2021. PMID: 33991113 Free PMC article.
State-dependent vs. central motor effects of ethanol on breathing.
Vecchio LM, Grace KP, Liu H, Harding S, Lê AD, Horner RL. Vecchio LM, et al. J Appl Physiol (1985). 2010 Feb;108(2):387-400. doi: 10.1152/japplphysiol.00797.2009. Epub 2009 Nov 19. J Appl Physiol (1985). 2010. PMID: 19926825 Free article.
Increased vesicular monoamine transporter enhances dopamine release and opposes Parkinson disease-related neurodegeneration in vivo.
Lohr KM, Bernstein AI, Stout KA, Dunn AR, Lazo CR, Alter SP, Wang M, Li Y, Fan X, Hess EJ, Yi H, Vecchio LM, Goldstein DS, Guillot TS, Salahpour A, Miller GW. Lohr KM, et al. Among authors: vecchio lm. Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9977-82. doi: 10.1073/pnas.1402134111. Epub 2014 Jun 16. Proc Natl Acad Sci U S A. 2014. PMID: 24979780 Free PMC article.
Increased expression of the dopamine transporter leads to loss of dopamine neurons, oxidative stress and l-DOPA reversible motor deficits.
Masoud ST, Vecchio LM, Bergeron Y, Hossain MM, Nguyen LT, Bermejo MK, Kile B, Sotnikova TD, Siesser WB, Gainetdinov RR, Wightman RM, Caron MG, Richardson JR, Miller GW, Ramsey AJ, Cyr M, Salahpour A. Masoud ST, et al. Among authors: vecchio lm. Neurobiol Dis. 2015 Feb;74:66-75. doi: 10.1016/j.nbd.2014.10.016. Epub 2014 Oct 30. Neurobiol Dis. 2015. PMID: 25447236 Free PMC article.