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Page 1
Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer's Disease.
Chen WT, Lu A, Craessaerts K, Pavie B, Sala Frigerio C, Corthout N, Qian X, Laláková J, Kühnemund M, Voytyuk I, Wolfs L, Mancuso R, Salta E, Balusu S, Snellinx A, Munck S, Jurek A, Fernandez Navarro J, Saido TC, Huitinga I, Lundeberg J, Fiers M, De Strooper B. Chen WT, et al. Among authors: wolfs l. Cell. 2020 Aug 20;182(4):976-991.e19. doi: 10.1016/j.cell.2020.06.038. Epub 2020 Jul 22. Cell. 2020. PMID: 32702314 Free article.
Astrocyte calcium dysfunction causes early network hyperactivity in Alzheimer's disease.
Shah D, Gsell W, Wahis J, Luckett ES, Jamoulle T, Vermaercke B, Preman P, Moechars D, Hendrickx V, Jaspers T, Craessaerts K, Horré K, Wolfs L, Fiers M, Holt M, Thal DR, Callaerts-Vegh Z, D'Hooge R, Vandenberghe R, Himmelreich U, Bonin V, De Strooper B. Shah D, et al. Among authors: wolfs l. Cell Rep. 2022 Aug 23;40(8):111280. doi: 10.1016/j.celrep.2022.111280. Cell Rep. 2022. PMID: 36001964 Free PMC article.
The Major Risk Factors for Alzheimer's Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques.
Sala Frigerio C, Wolfs L, Fattorelli N, Thrupp N, Voytyuk I, Schmidt I, Mancuso R, Chen WT, Woodbury ME, Srivastava G, Möller T, Hudry E, Das S, Saido T, Karran E, Hyman B, Perry VH, Fiers M, De Strooper B. Sala Frigerio C, et al. Among authors: wolfs l. Cell Rep. 2019 Apr 23;27(4):1293-1306.e6. doi: 10.1016/j.celrep.2019.03.099. Cell Rep. 2019. PMID: 31018141 Free PMC article.
Stem-cell-derived human microglia transplanted in mouse brain to study human disease.
Mancuso R, Van Den Daele J, Fattorelli N, Wolfs L, Balusu S, Burton O, Liston A, Sierksma A, Fourne Y, Poovathingal S, Arranz-Mendiguren A, Sala Frigerio C, Claes C, Serneels L, Theys T, Perry VH, Verfaillie C, Fiers M, De Strooper B. Mancuso R, et al. Among authors: wolfs l. Nat Neurosci. 2019 Dec;22(12):2111-2116. doi: 10.1038/s41593-019-0525-x. Epub 2019 Oct 28. Nat Neurosci. 2019. PMID: 31659342
Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer's disease.
Walgrave H, Balusu S, Snoeck S, Vanden Eynden E, Craessaerts K, Thrupp N, Wolfs L, Horré K, Fourne Y, Ronisz A, Silajdžić E, Penning A, Tosoni G, Callaerts-Vegh Z, D'Hooge R, Thal DR, Zetterberg H, Thuret S, Fiers M, Frigerio CS, De Strooper B, Salta E. Walgrave H, et al. Among authors: wolfs l. Cell Stem Cell. 2021 Oct 7;28(10):1805-1821.e8. doi: 10.1016/j.stem.2021.05.001. Epub 2021 May 24. Cell Stem Cell. 2021. PMID: 34033742 Free article.
microRNA-132 regulates gene expression programs involved in microglial homeostasis.
Walgrave H, Penning A, Tosoni G, Snoeck S, Davie K, Davis E, Wolfs L, Sierksma A, Mars M, Bu T, Thrupp N, Zhou L, Moechars D, Mancuso R, Fiers M, Howden AJM, De Strooper B, Salta E. Walgrave H, et al. Among authors: wolfs l. iScience. 2023 May 6;26(6):106829. doi: 10.1016/j.isci.2023.106829. eCollection 2023 Jun 16. iScience. 2023. PMID: 37250784 Free PMC article.
The γ-secretase substrate proteome and its role in cell signaling regulation.
Hou P, Zielonka M, Serneels L, Martinez-Muriana A, Fattorelli N, Wolfs L, Poovathingal S, T'Syen D, Balusu S, Theys T, Fiers M, Mancuso R, Howden AJM, De Strooper B. Hou P, et al. Among authors: wolfs l. Mol Cell. 2023 Nov 16;83(22):4106-4122.e10. doi: 10.1016/j.molcel.2023.10.029. Epub 2023 Nov 16. Mol Cell. 2023. PMID: 37977120 Free article.
Xenografted human microglia display diverse transcriptomic states in response to Alzheimer's disease-related amyloid-β pathology.
Mancuso R, Fattorelli N, Martinez-Muriana A, Davis E, Wolfs L, Van Den Daele J, Geric I, Premereur J, Polanco P, Bijnens B, Preman P, Serneels L, Poovathingal S, Balusu S, Verfaillie C, Fiers M, De Strooper B. Mancuso R, et al. Among authors: wolfs l. Nat Neurosci. 2024 Mar 27. doi: 10.1038/s41593-024-01600-y. Online ahead of print. Nat Neurosci. 2024. PMID: 38539015
12 results