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Oral administration of non-absorbable delayed release 6-mercaptopurine is locally active in the gut, exerts a systemic immune effect and alleviates Crohn's disease with low rate of side effects: results of double blind Phase II clinical trial.
Israeli E, Goldin E, Fishman S, Konikoff F, Lavy A, Chowers Y, Melzer E, Lahat A, Mahamid M, Shirin H, Nussinson E, Segol O, Ya'acov AB, Shabbat Y, Ilan Y. Israeli E, et al. Among authors: ya acov ab. Clin Exp Immunol. 2015 Aug;181(2):362-72. doi: 10.1111/cei.12640. Clin Exp Immunol. 2015. PMID: 25846055 Free PMC article. Clinical Trial.