[HTML][HTML] The nucleoside analog GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies
BG Murphy, M Perron, E Murakami, K Bauer… - Veterinary …, 2018 - Elsevier
Feline infectious peritonitis (FIP) is a common and highly lethal coronavirus disease of
domestic cats. Recent studies of diseases caused by several RNA viruses in people and
other species indicate that antiviral therapy may be effective against FIP in cats. The small
molecule nucleoside analog GS-441524 is a molecular precursor to a pharmacologically
active nucleoside triphosphate molecule. These analogs act as an alternative substrate and
RNA-chain terminator of viral RNA dependent RNA polymerase. We determined that GS …
domestic cats. Recent studies of diseases caused by several RNA viruses in people and
other species indicate that antiviral therapy may be effective against FIP in cats. The small
molecule nucleoside analog GS-441524 is a molecular precursor to a pharmacologically
active nucleoside triphosphate molecule. These analogs act as an alternative substrate and
RNA-chain terminator of viral RNA dependent RNA polymerase. We determined that GS …