[HTML][HTML] Architecture of the SARS coronavirus prefusion spike
DR Beniac, A Andonov, E Grudeski… - Nature structural & …, 2006 - nature.com
DR Beniac, A Andonov, E Grudeski, TF Booth
Nature structural & molecular biology, 2006•nature.comThe emergence in 2003 of a new coronavirus (CoV) responsible for the atypical pneumonia
termed severe acute respiratory syndrome (SARS) was a stark reminder that hitherto
unknown viruses have the potential to cross species barriers to become new human
pathogens. Here we describe the SARS-CoV'spike'structure determined by single-particle
cryo-EM, along with the docked atomic structures of the receptor-binding domain and
prefusion core.
termed severe acute respiratory syndrome (SARS) was a stark reminder that hitherto
unknown viruses have the potential to cross species barriers to become new human
pathogens. Here we describe the SARS-CoV'spike'structure determined by single-particle
cryo-EM, along with the docked atomic structures of the receptor-binding domain and
prefusion core.
Abstract
The emergence in 2003 of a new coronavirus (CoV) responsible for the atypical pneumonia termed severe acute respiratory syndrome (SARS) was a stark reminder that hitherto unknown viruses have the potential to cross species barriers to become new human pathogens. Here we describe the SARS-CoV 'spike' structure determined by single-particle cryo-EM, along with the docked atomic structures of the receptor-binding domain and prefusion core.
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