Because chronic neuroinflammation is a hallmark of neurodegenerative diseases and
compromises neuron viability, it is imperative to discover pharmacologic targets to modulate the …

Autophagy is a highly coordinated process that is controlled at several levels including
transcriptional regulation. Here, we identify the transcription factor NFE2L2/NRF2 (nuclear factor, …

Aims: This preclinical study was aimed at determining whether pharmacological targeting of
transcription factor NRF2, a master controller of many homeostatic genes, might provide a …

Parkinson's disease (PD) is the second most common neurodegenerative disorder
characterized by the degeneration of dopaminergic neurons of the substantia nigra and the …

Acute respiratory distress syndrome (ARDS) caused by SARS-CoV-2 is largely the result of
a dysregulated host response, followed by damage to alveolar cells and lung fibrosis. …

TAU protein aggregation is the main characteristic of neurodegenerative diseases known
as tauopathies. Low-grade chronic inflammation is also another hallmark that indicates …

Chronic neuroinflammation is a hallmark of the onset and progression of brain
proteinopathies such as Alzheimer disease (AD) and it is suspected to participate in the …

Microglial cells are essential mediators of neuroinflammatory processes involved in several
pathologies. Moreover, the chemokine fractalkine (CX3CL1) is essential in the crosstalk …

Non-alcoholic steatohepatitis (NASH) is a common chronic liver disease that compromises
liver function, for which there is not a specifically approved medicine. Recent research has …

TAU protein aggregation is the main characteristic of neurodegenerative diseases known
as tauopathies. Low-grade chronic inflammation is also another hallmark that indicates …