Physical activity has been reported to improve cognitive function in humans and rodents,
possibly via a brain-derived neurotrophic factor (BDNF)-regulated mechanism. In this study of …

Microgliosis and astrogliosis are standard pathological features of neurodegenerative disease.
Microglia are primed by chronic neurodegeneration such that toll-like receptor agonists, …

Systemic inflammation can impair cognition with relevance to dementia, delirium and post-operative
cognitive dysfunction. Episodes of delirium also contribute to rates of long-term …

… injection of Avertin (2,2,2-tribromoethanol 50% w/v in tertiary amyl alcohol, diluted 1:40 in H
… of a 10% w/v scrapie (ME7 strain)-infected C57BL/6 brain homogenate [or 10% w/v normal …

… Author links open overlay panel Carol Murray a b , Éadaoin W. Griffin a b , Elaine O’Loughlin
b , Aoife Lyons b , Eoin Sherwin b , Suaad Ahmed a , Nigel J Stevenson a , Andrew Harkin …

Short periods of forced exercise have been reported to selectively induce enhancements in
hippocampal‐dependent cognitive function, possibly via brain‐derived neurotrophic factor (…

The potential of exercise or environmental enrichment to prevent or reverse age‐related
cognitive decline in rats has been widely investigated. The data suggest that the efficacy of …

Evidence indicates that noradrenaline elicits anti-inflammatory actions in the central nervous
system (CNS), and plays a neuroprotective role where inflammatory events contribute to …

Excitotoxicity is a mechanism of neuronal cell death implicated in a range of neurodegenerative
conditions. Systemic administration of the excitotoxin kainic acid (KA) induces …

Locus coeruleus (LC)-derived noradrenaline is important in cognition and decreases with
age, but the impact of prior noradrenaline deficiency on vulnerability to inflammation-induced …