User profiles for Óttar Rolfsson

Óttar Rolfsson

Assistant Professor of Biochemistry and Systems Biology, University of Iceland
Verified email at hi.is
Cited by 3933

Biomarkers defining the metabolic age of red blood cells during cold storage

G Paglia, A D'Alessandro, Ó Rolfsson… - Blood, The Journal …, 2016 - ashpublications.org
Metabolomic investigations of packed red blood cells (RBCs) stored under refrigerated
conditions in saline adenine glucose mannitol (SAGM) additives have revealed the presence of 3 …

[HTML][HTML] Direct evidence for packaging signal-mediated assembly of bacteriophage MS2

Ó Rolfsson, S Middleton, IW Manfield, SJ White… - Journal of molecular …, 2016 - Elsevier
Using cross-linking coupled to matrix-assisted laser desorption/ionization mass spectrometry
and CLIP-Seq sequencing, we determined the peptide and oligonucleotide sequences at …

A community-driven global reconstruction of human metabolism

…, MK Aurich, H Haraldsdottir, ML Mo, O Rolfsson… - Nature …, 2013 - nature.com
Multiple models of human metabolism have been reconstructed, but each represents only a
subset of our knowledge. Here we describe Recon 2, a community-driven, consensus '…

[HTML][HTML] Current status and future prospects of genome-scale metabolic modeling to optimize the use of mesenchymal stem cells in regenerative medicine

Ţ Sigmarsdóttir, S McGarrity, Ó Rolfsson… - … in Bioengineering and …, 2020 - frontiersin.org
Mesenchymal stem cells are a promising source for externally grown tissue replacements
and patient-specific immunomodulatory treatments. This promise has not yet been fulfilled in …

Comprehensive metabolomic study of platelets reveals the expression of discrete metabolic phenotypes during storage

G Paglia, ÓE Sigurjónsson, Ó Rolfsson… - …, 2014 - Wiley Online Library
Background Platelet ( PLT ) concentrates are routinely stored for 5 to 7 days. During storage
they exhibit what has been termed PLT storage lesion ( PSL ), which is evident by a loss of …

[HTML][HTML] Metabolic re-wiring of isogenic breast epithelial cell lines following epithelial to mesenchymal transition

…, GM Mćlandsmo, S Gudmundsson, Ó Rolfsson - Cancer letters, 2017 - Elsevier
Epithelial to mesenchymal transition (EMT) has implications in tumor progression and metastasis.
Metabolic alterations have been described in cancer development but studies focused …

Metabolomic analysis of platelets during storage: a comparison between apheresis‐and buffy coat–derived platelet concentrates

G Paglia, ÓE Sigurjónsson, Ó Rolfsson… - …, 2015 - Wiley Online Library
Background Platelet concentrates ( PC s) can be prepared using three methods: platelet (
PLT )‐rich plasma, apheresis, and buffy coat. The aim of this study was to obtain a …

[HTML][HTML] Linkage of Osteoporosis to Chromosome 20p12 and Association to BMP2

U Styrkarsdottir, JB Cazier, A Kong, O Rolfsson… - PLoS …, 2003 - journals.plos.org
Osteoporotic fractures are a major cause of morbidity and mortality in ageing populations.
Osteoporosis, defined as low bone mineral density (BMD) and associated fractures, have …

Ion mobility derived collision cross sections to support metabolomics applications

…, S Halldórsson, O Rolfsson… - Analytical …, 2014 - ACS Publications
Metabolomics is a rapidly evolving analytical approach in life and health sciences. The
structural elucidation of the metabolites of interest remains a major analytical challenge in the …

Metabolic fate of adenine in red blood cells during storage in SAGM solution

G Paglia, ÓE Sigurjónsson, A Bordbar, Ó Rolfsson… - …, 2016 - Wiley Online Library
BACKGROUND Red blood cells (RBCs) are routinely stored and transfused worldwide.
Recently, metabolomics have shown that RBCs experience a three‐phase metabolic decay …