First- and second-generation sequencing technologies have led the way in revolutionizing
the field of genomics and beyond, motivating an astonishing number of scientific advances, …

Genomic sequencing has made it clear that a large fraction of the genes specifying the core
biological functions are shared by all eukaryotes. Knowledge of the biological role of such …

Background A large outbreak of diarrhea and the hemolytic–uremic syndrome caused by an
unusual serotype of Shiga-toxin–producing Escherichia coli (O104:H4) began in Germany …

Genetic variants that are associated with common human diseases do not lead directly to
disease, but instead act on intermediate, molecular phenotypes that in turn induce changes in …

Cardiovascular disease is the leading cause of mortality in the world, and the increasing
burden is largely a consequence of modifiable behavioral risk factors that interact with …

Background Although cholera has been present in Latin America since 1991, it had not
been epidemic in Haiti for at least 100 years. Recently, however, there has been a severe …

Major depressive disorder (MDD) is a leading cause of disease burden worldwide. While
the incidence, symptoms and treatment of MDD all point toward major sex differences, the …

We direct your readers' attention to the principles and guidelines (Supplementary Guidelines)
developed by the Next-generation Sequencing: Standardization of Clinical Testing (Nex-…

The Stanford Microarray Database (SMD) stores raw and normalized data from microarray
experiments, and provides web interfaces for researchers to retrieve, analyze and visualize …

New York City (NYC) has emerged as one of the epicenters of the current severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. To identify the early transmission …