Although distant metastases account for most of the deaths in cancer patients, fundamental
questions regarding mechanisms that promote or inhibit metastasis remain unanswered. We …

Background The estimation of risk of recurrence for patients with colon carcinoma must be
improved. A robust immune score quantification is needed to introduce immune parameters …

We examined how the immune microenvironment molds tumor evolution at different metastatic
organs in a longitudinal dataset of colorectal cancer. Through multiplexed analyses, we …

Early detection and treatment are critical for improving the outcome of patients with cancer 1
. Understanding the largely uncharted biology of carcinogenesis requires deciphering …

Treatment of metastatic colorectal cancer is based upon the assumption that metastases are
homogeneous within a patient. We quantified immune cell types of 603 whole-slide …

Background This study assesses how the metastatic immune landscape is impacting the
response to treatment and the outcome of colorectal cancer (CRC) patients. Methods Complete …

The aim of therapeutic dendritic cell (DC) vaccines in cancer immunotherapy is to activate
cytotoxic T cells to recognize and attack the tumor. T cell activation requires the interaction of …

Cancer invasion into an extracellular matrix (ECM) results from a biophysical reciprocal
interplay between the expanding cancer lesion and tissue barriers imposed by the adjacent …

Background An unresolved question in coeliac disease is to understand how some toxic
gliadin peptides, in particular p31–43, can initiate an innate response and lead to tissue …

Cystic fibrosis (CF) is a monogenic disease caused by mutations in the CF transmembrane
conductance regulator (CFTR) gene. CF is characterized by chronic bacterial lung infections …