User profiles for A. A. Aravin
 | Alexei AravinProfessor, Division of Biology and Biological Engineering, California Institute of Technology Verified email at caltech.edu Cited by 30524 |
PIWI-interacting small RNAs: the vanguard of genome defence
PIWI-interacting RNAs (piRNAs) are a distinct class of small non-coding RNAs that form the
piRNA-induced silencing complex (piRISC) in the germ line of many animal species. The …
piRNA-induced silencing complex (piRISC) in the germ line of many animal species. The …
The Piwi-piRNA pathway provides an adaptive defense in the transposon arms race
Increasingly complex networks of small RNAs act through RNA-interference (RNAi) pathways
to regulate gene expression, to mediate antiviral responses, to organize chromosomal …
to regulate gene expression, to mediate antiviral responses, to organize chromosomal …
piRNA Biogenesis in Drosophila melanogaster
The PIWI-interacting RNA (piRNA) pathway is a conserved defense system that protects the
genome integrity of the animal germline from deleterious transposable elements. Targets of …
genome integrity of the animal germline from deleterious transposable elements. Targets of …
[HTML][HTML] Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila
Drosophila Piwi-family proteins have been implicated in transposon control. Here, we examine
piwi-interacting RNAs (piRNAs) associated with each Drosophila Piwi protein and find …
piwi-interacting RNAs (piRNAs) associated with each Drosophila Piwi protein and find …
[PDF][PDF] A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice
piRNAs and Piwi proteins have been implicated in transposon control and are linked to
transposon methylation in mammals. Here we examined the construction of the piRNA system in …
transposon methylation in mammals. Here we examined the construction of the piRNA system in …
[PDF][PDF] The small RNA profile during Drosophila melanogaster development
… from both strands of Su(Ste) (Aravin et al., 2001). A study and … Class II elements are (AA,
unpublished data). The clustering … in of some transposable elements in the germline (Aravin …
unpublished data). The clustering … in of some transposable elements in the germline (Aravin …
Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes
Pseudogenes populate the mammalian genome as remnants of artefactual incorporation of
coding messenger RNAs into transposon pathways 1 . Here we show that a subset of …
coding messenger RNAs into transposon pathways 1 . Here we show that a subset of …
Developmentally regulated piRNA clusters implicate MILI in transposon control
AA Aravin, R Sachidanandam, A Girard, K Fejes-Toth… - Science, 2007 - science.org
Nearly half of the mammalian genome is composed of repeated sequences. In Drosophila,
Piwi proteins exert control over transposons. However, mammalian Piwi proteins, MIWI and …
Piwi proteins exert control over transposons. However, mammalian Piwi proteins, MIWI and …
[PDF][PDF] Double-stranded RNA-mediated silencing of genomic tandem repeats and transposable elements in the D. melanogaster germline
Background: The injection of double-stranded RNA (dsRNA) has been shown to induce a
potent sequence-specific inhibition of gene function in diverse invertebrate and vertebrate …
potent sequence-specific inhibition of gene function in diverse invertebrate and vertebrate …
An epigenetic role for maternally inherited piRNAs in transposon silencing
In plants and mammals, small RNAs indirectly mediate epigenetic inheritance by specifying
cytosine methylation. We found that small RNAs themselves serve as vectors for epigenetic …
cytosine methylation. We found that small RNAs themselves serve as vectors for epigenetic …