Arcuate nucleus neurons are known to be responsive to a wide array of hormones and nutrients,
including leptin, insulin, gonadal steroids and glucose. In addition to potential transport …

▪ Abstract The traditionally accepted theory has been that most of the biological effects of
growth hormone (GH) are mediated by circulating (endocrine) insulin-like growth factor-I (IGF-I). …

Defining the molecular mechanisms linking obe-sity with insulin resistance is important for
developing new therapies against the rising incidence of type 2 diabetes in industrialized …

The central meilanocortin system is critical for the long term regulation of energy homeostasis.
Null mutations of the melanocortin-4 receptor (MC4-R) are associated with hyperphagia, …

Synchronizing rhythms of behaviour and metabolic processes is important for cardiovascular
health and preventing metabolic diseases. The nuclear receptors REV-ERB-α and REV-…

… RIKEN cDNA 2310040A07 encodes a short (<1 kb) mRNA, encoding a highly conserved
76 aa open reading frame (ORF) (Figures 1A and 1B). Bioinformatics analysis using SignalP …

The neural pathways through which central serotonergic systems regulate food intake and
body weight remain to be fully elucidated. We report that serotonin, via action at serotonin1B …

Disruptions of the melanocortin signaling system have been linked to obesity. We investigated
a possible role of the central nervous melanocortin system (CNS-Mcr) in the control of …

Adropin is a secreted peptide that improves hepatic steatosis and glucose homeostasis
when administered to diet‐induced obese mice. It is not clear if adropin is a peptide hormone …

In response to moderately increased dietary fat content, melanocortin-4 receptor-null mutant
(MC4R−/−) mice exhibit hyperphagia and accelerated weight gain compared to wild-type …