… This results in breakdown of membrane glycerophospholipids with the release of arachidonic
acid (AA) and … Farooqui for providing figures and his help in preparation of this review. …

Neural membranes contain several classes of glycerophospholipids which turnover at different
rates with respect to their structure and localization in different cells and membranes. The …

The initial mechanical tissue disruption of spinal cord injury (SCI) is followed by a period of
secondary injury that increases the size of the lesion. The secondary injury has long been …

Three enzyme systems, cyclooxygenases that generate prostaglandins, lipoxygenases that
form hydroxy derivatives and leukotrienes, and epoxygenases that give rise to …

… factors, endotoxins, or oxygen free radicals, AA is released from immune cell
glycerophospholipids by the action of phospholipase A 2 . The AA is metabolized to eicosanoids, a …

The phospholipase A 2 family includes secretory phospholipase A 2 , cytosolic
phospholipase A 2 , plasmalogen-selective phospholipase A 2 , and calcium-independent …

Phospholipase A 2 (PLA 2 ) is the name for the class of lipolytic enzymes that hydrolyze the
acyl group from the sn‐2 position of glycerophospholipids, generating free fatty acids and …

… AA and DHA cannot be synthesized de novo by mammals; they, or their precursors, must be
… (Horrocks and Farooqui, 2004, Marszalek and Lodish, 2005, Farooqui, 2009). AA is found in …

Phospholipase A2 (PLA2) generates arachidonic acid, docosahexaenoic acid, and
lysophospholipids from neural membrane phospholipids. These metabolites have a variety of …

The metabolic syndrome is a cluster of common pathologies: abdominal obesity linked to an
excess of visceral fat, insulin resistance, dyslipidemia and hypertension. At the molecular …