The oocyte epigenome plays critical roles in mammalian gametogenesis and embryogenesis.
Yet, how it is established remains elusive. Here, we report that histone-lysine N-…

Critical roles for DNA methylation in embryonic development are well established, but less
is known about its roles during trophoblast development, the extraembryonic lineage that …

Silencing of a subset of germline genes is dependent upon DNA methylation (DNAme) post-implantation.
However, these genes are generally hypomethylated in the blastocyst, …

Several imprinted genes have been implicated in the regulation of placental function and
embryonic growth. On distal mouse chromosome 7, two clusters of imprinted genes, each …

Imprinted genes are expressed from a single parental allele, with the other allele often
silenced by DNA methylation (DNAme) established in the germline. While species-specific …

Background X-chromosome inactivation is a striking example of epigenetic silencing in
which expression of the long non-coding RNA XIST initiates the heterochromatinization and …

DNA methylation (DNAme; 5-methylcytosine, 5mC) plays an essential role in mammalian
development, and the 5mC profile is regulated by a balance of opposing enzymatic activities: …

The basic helix-loop-helix (bHLH) transcription factor ASCL2 plays essential roles in diploid
multipotent trophoblast progenitors, intestinal stem cells, follicular T-helper cells, as well as …

The gene Mest (also known as Peg1 ) is regulated by genomic imprinting in the mouse and
only the paternal allele is active for transcription. MEST is similarly imprinted in humans, …

Background Allele-specific transcriptional regulation, including of imprinted genes, is essential
for normal mammalian development. While the regulatory regions controlling imprinted …