The Library of Integrated Network-Based Cellular Signatures (LINCS) is an NIH Common
Fund program that catalogs how human cells globally respond to chemical, genetic, and …

RNA sequencing (RNA-seq) is the leading technology for genome-wide transcript quantification.
However, publicly available RNA-seq data is currently provided mostly in raw form, a …

Identifying the transcription factors (TFs) responsible for observed changes in gene expression
is an important step in understanding gene regulatory networks. ChIP-X Enrichment …

Connectivity mapping resources consist of signatures representing changes in cellular state
following systematic small-molecule, disease, gene, or other form of perturbations. Such …

While gene expression data at the mRNA level can be globally and accurately measured,
profiling the activity of cell signaling pathways is currently much more difficult. …

Motivation As part of the NIH Library of Integrated Network-based Cellular Signatures
program, hundreds of thousands of transcriptomic signatures were generated with the L1000 …

The frequency by which genes are studied correlates with the prior knowledge accumulated
about them. This leads to an imbalance in research attention where some genes are highly …

High-throughput experiments produce increasingly large datasets that are difficult to analyze
and integrate. While most data integration approaches focus on aligning metadata, data …

The parasitic protozoan, Leishmania, survives in harsh environments within its mammalian
and sand fly hosts. Secreted proteins likely play critical roles in the parasite’s interactions …

Faraday rotation is a valuable diagnostic tool for investigating laboratory and astrophysical
plasmas, but it has almost exclusively been treated in the collisionless limit (despite the non-…