Insomnia is the second most prevalent mental disorder, with no sufficient treatment available.
Despite substantial heritability, insight into the associated genes and neurobiological …

The mammalian cerebral cortex supports cognitive functions such as sensorimotor
integration, memory, and social behaviors. Normal brain function relies on a diverse set of …

Intelligence is highly heritable 1 and a major determinant of human health and well-being 2
. Recent genome-wide meta-analyses have identified 24 genomic loci linked to variation in …

Neuroticism is an important risk factor for psychiatric traits, including depression 1 , anxiety 2
, 3 , and schizophrenia 4 , 5 – 6 . At the time of analysis, previous genome-wide association …

With few exceptions, the marked advances in knowledge about the genetic basis of schizophrenia
have not converged on findings that can be confidently used for precise experimental …

Oligodendrocytes have been considered as a functionally homogeneous population in the
central nervous system (CNS). We performed single-cell RNA sequencing on 5072 cells of …

Striatal locally projecting neurons, or interneurons, act on nearby circuits and shape
functional output to the rest of the basal ganglia. We performed single-cell RNA sequencing of …

Understanding the function of a tissue requires knowing the spatial organization of its
constituent cell types. In the cerebral cortex, single-cell RNA sequencing (scRNA-seq) has …

Despite the different animal models of Parkinson's disease developed during the last years,
they still present limitations modelling the slow and progressive process of …

Variance in IQ is associated with a wide range of health outcomes, and 1% of the population
are affected by intellectual disability. Despite a century of research, the fundamental neural …