Pluripotent stem cells (PSCs) can self-renew or differentiate from naive or more differentiated,
primed, pluripotent states established by specific culture conditions. Increased intracellular …

The initiation of cell division integrates a large number of intra- and extracellular inputs. D-type
cyclins (hereafter, cyclin D) couple these inputs to the initiation of DNA replication 1 . …

… AC Chaikovsky was supported by the Stanford Cancer Biology training grant (T32 CA009302)…
SK Denny, AC Chaikovsky, and Y. Ouadah were supported by the NSF GRFP. JS Lim was …

Proliferative control in cancer cells is frequently disrupted by mutations in the retinoblastoma
protein (RB) pathway. Intriguingly, RB1 mutations can arise late in tumorigenesis in cancer …

Inhibitors of the cyclin-dependent kinases 4 and 6 (CDK4/6) were originally designed to
block proliferation and cell cycle progression of cancer cells in which the activity of these …

The retinoblastoma (RB) tumor suppressor is functionally inactivated in a wide range of
human tumors where this inactivation promotes tumorigenesis in part by allowing uncontrolled …

D-type cyclins (cyclin D1, D2, and D3, together cyclin D) are central drivers of the cell division
cycle and well-described proto-oncoproteins. Rapid turnover of cyclin D is critical for its …

… Cyclin D has a short half-life throughout the cell cycle48; however, phosphorylation of a C-terminal
degron is thought to accelerate polyubiquitylation and degradation of cyclin D at the …

… Our accounts are as follows: you told me that I should receive from you 335 rubles, including
100 for The Snow Maiden. I think that in the light of the less than brilliant success of this …

… The revealed decrease in the colony-stimulating activity of supernatants obtained by culturing
neuroglia in the presence of a toxic agent could be associated with both a decrease in the …