The diarylquinoline TMC207 kills Mycobacterium tuberculosis by specifically inhibiting ATP
synthase. We show here that human mitochondrial ATP synthase (50% inhibitory …

Single-molecule fluorescence spectroscopy has proven to be instrumental in understanding
a wide range of biological phenomena at the nanoscale. Important examples of what this …

Type III CRISPR-Cas immunity is widespread in prokaryotes and is generally mediated by
multisubunit effector complexes. These complexes recognize complementary viral transcripts …

Infections with Mycobacterium tuberculosis are substantially increasing on a worldwide
scale and new antibiotics are urgently needed to combat concomitantly emerging drug-resistant …

… Although the first nucleotide of PFS forms a partially frayed A•C pair, the rest of PFS pivots
toward the surface of the TPR (Fig. 5C). The switch helix is dislodged from the shackle of the …

CRISPR-Cas systems adapt their immunological memory against their invaders by integrating
short DNA fragments into clustered regularly interspaced short palindromic repeat (…

The RNA-binding protein TRBP is a central component of the Dicer complex. Despite a
decade of biochemical and structural studies, the essential functionality of TRBP in microRNA (…

ATP synthase is a validated drug target for the treatment of tuberculosis, and ATP synthase
inhibitors are promising candidate drugs for the treatment of infections caused by other slow-…

Prokaryotes adapt to challenges from mobile genetic elements by integrating spacers
derived from foreign DNA in the CRISPR array 1 . Spacer insertion is carried out by the Cas1–…

Pyrazinoic acid, the active form of the first-line antituberculosis drug pyrazinamide, decreased
the proton motive force and respiratory ATP synthesis rates in subcellular mycobacterial …