… A human cDNA encoding NPC1 (Origene) was ligated in-frame to a triple Flag sequence
and the resulting gene encoding a C-terminally Flag-tagged NPC1 protein was subcloned into …

Lighter variations of pigmentation in humans are associated with diminished number, size,
and density of melanosomes, the pigmented organelles of melanocytes. Here we show that …

… An electrode is provided underneath the free–free beam to allow electrostatic excitation
via an applied ac voltage . The electrical operation of this structure is very similar to that of …

Exercise exerts a wide range of beneficial effects for healthy physiology 1. However, the
mechanisms regulating an individual’s motivation to engage in physical activity remain …

To identify approaches to target DNA repair vulnerabilities in cancer, we discovered
nanomolar potent, selective, low molecular weight (MW), allosteric inhibitors of the polymerase …

Colorectal cancer (CRC) is among the most frequent forms of cancer, and new strategies for
its prevention and therapy are urgently needed 1 . Here we identify a metabolite signalling …

Bacillus cereus causes exotoxin-mediated diarrheal food poisoning. Hemolysin BL (HBL) is
a well-characterized B. cereus toxin composed of three components (B, L1, and L2) that …

INTRODUCTION The microbiota promotes the maturation and homeostasis of the immune
system, in part through the release of microbial products. Early-life microbial colonization has …

Relatively small changes in particle size and other parameters which affect interparticle
forces can transform a fine free-flowing powder into one which is cohesive. The influence of …

Post-acute sequelae of COVID-19 (PASC, "Long COVID") pose a significant global health
challenge. The pathophysiology is unknown, and no effective treatments have been found to …