[HTML][HTML] Genetic mechanisms of critical illness in COVID-19
Host-mediated lung inflammation is present 1 , and drives mortality 2 , in the critical illness
caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with …
caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with …
Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals
…, N Eriksson, SE Bergen, TS Boutin, AD Bretherick… - Nature …, 2020 - nature.com
Circulating proteins are vital in human health and disease and are frequently used as
biomarkers for clinical decision-making or as targets for pharmacological intervention. Here, we …
biomarkers for clinical decision-making or as targets for pharmacological intervention. Here, we …
Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation
Characterizing genetic influences on DNA methylation (DNAm) provides an opportunity to
understand mechanisms underpinning gene regulation and disease. In the present study, we …
understand mechanisms underpinning gene regulation and disease. In the present study, we …
[HTML][HTML] GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19
Critical illness in COVID-19 is an extreme and clinically homogeneous disease phenotype
that we have previously shown 1 to be highly efficient for discovery of genetic associations 2 . …
that we have previously shown 1 to be highly efficient for discovery of genetic associations 2 . …
Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances
10.7554/eLife.39856.001 We use a genome-wide association of 1 million parental lifespans
of genotyped subjects and data on mortality risk factors to validate previously unreplicated …
of genotyped subjects and data on mortality risk factors to validate previously unreplicated …
[PDF][PDF] Genome‐Wide association study of NAFLD using electronic health records
Genome‐wide association studies (GWAS) have identified several risk loci for nonalcoholic
fatty liver disease (NAFLD). Previous studies have largely relied on small sample sizes and …
fatty liver disease (NAFLD). Previous studies have largely relied on small sample sizes and …
Genetic landscape of the ACE2 coronavirus receptor
…, E Pairo-Castineira, S Clohisey, AD Bretherick… - Circulation, 2022 - Am Heart Assoc
… Dr Bretherick acknowledges funding from the Wellcome PhD training fellowship for
clinicians (204979/Z/16/Z), the Edinburgh Clinical Academic Track program. Dr Reiner was …
clinicians (204979/Z/16/Z), the Edinburgh Clinical Academic Track program. Dr Reiner was …
Genomic and phenomic insights from an atlas of genetic effects on DNA methylation
Characterizing genetic influences on DNA methylation (DNAm) provides an opportunity to
understand mechanisms underpinning gene regulation and disease. Here we describe …
understand mechanisms underpinning gene regulation and disease. Here we describe …
Acute liver failure in Scotland between 1992 and 2009; incidence, aetiology and outcome
AD Bretherick, DGN Craig, G Masterton… - … Journal of Medicine, 2011 - academic.oup.com
Aim: To describe incidence, aetiology and outcome data for Scotland since the inception of
the Scottish Liver Transplant Unit (SLTU) in 1992. Background: Acute liver failure (ALF) is a …
the Scottish Liver Transplant Unit (SLTU) in 1992. Background: Acute liver failure (ALF) is a …
[PDF][PDF] Genome‐wide analysis identifies gallstone‐susceptibility loci including genes regulating gastrointestinal motility
Background and Aims Genome‐wide association studies (GWAS) have identified several
risk loci for gallstone disease. As with most polygenic traits, it is likely that many genetic …
risk loci for gallstone disease. As with most polygenic traits, it is likely that many genetic …