Chromosomes of eukaryotes adopt highly dynamic and complex hierarchical structures in
the nucleus. The three-dimensional (3D) organization of chromosomes profoundly affects …

A large number of cis-regulatory sequences have been annotated in the human genome 1 ,
2 , but defining their target genes remains a challenge 3 . One strategy is to identify the long-…

Li, B, Mg and Ca isotopes became of increasing interest during the last decade due to their
potential for better constraining the carbon cycle and nutrient cycling. At the soil-water-plant …

… We would like to dedicate this manuscript in loving memory of Joseph Schmitt. We would like
to … ADS is supported by an NIH genetics training grant T32 GM008666. CLB is supported by …

After two decades of improvements, the current human reference genome (GRCh38) is the
most accurate and complete vertebrate genome ever produced. However, no single …

Understanding the diversity of human tissues is fundamental to disease and requires linking
genetic information, which is identical in most of an individual’s cells, with epigenetic …

Hepatocellular carcinoma (HCC) is the most rapidly increasing cause of cancer‐related
mortality in the United States. Because of the lack of viable treatment options for HCC, …

Formation of long-range chromatin loops is a crucial step in transcriptional activation of target
genes by distal enhancers [1-2]. Mapping such structural features can help define target …

… Davesne and AD Schmitt. (E) Thin section through acellular bone in the rib of an acanthomorph,
the sea bass Dicentrarchus labrax, showing numerous radially arranged osteoblastic …

In order to constrain the origin and fluxes of elements carried by rivers of high latitude
permafrost-dominated areas, major and trace element concentrations as well as Sr and U isotopic …