Mitochondria dynamically fuse and divide within cells, and the proper balance of fusion and
fission is necessary for normal mitochondrial function, morphology, and distribution. Drp1 is …

There is growing interest in the topic of intracellular phase transitions that lead to the
formation of biologically regulated biomolecular condensates. These condensates are …

Low-complexity protein domains promote the formation of various biomolecular condensates.
However, in many cases, the precise sequence features governing condensate formation …

Ribonucleoprotein bodies are exemplars of membraneless biomolecular condensates that
can form via spontaneous or driven phase transitions. The fungal protein Whi3 forms …

Huntingtin N-terminal fragments (Htt-NTFs) with expanded polyglutamine tracts form a range
of neurotoxic aggregates that are associated with Huntington's disease. Here, we show that …

Patterned substitution of d-amino acids into the primary sequences of self-assembling
peptides influences molecular-level packing and supramolecular morphology. We report that …

Cellular matter can be organized into compositionally distinct biomolecular condensates.
For example, in Ashbya gossypii, the RNA-binding protein Whi3 forms distinct condensates …

Glycine-rich regions feature prominently in intrinsically disordered regions (IDRs) of proteins
that drive phase separation and the regulated formation of membraneless biomolecular …

Transthyretin (TTR) is a homotetrameric protein that is found in the plasma and cerebrospinal
fluid. Dissociation of TTR tetramers sets off a downhill cascade of amyloid formation …

Over the last decade, evidence has accumulated to suggest that numerous instances of cellular
compartmentalization can be explained by the phenomenon of phase separation. This is …