The first stages of embryonic differentiation are driven by signaling pathways hardwired to
induce particular fates. Endoderm commitment is controlled by the TGF-β superfamily member…

The Xenopus embryo has provided key insights into fate specification, the cell cycle, and other
fundamental developmental and cellular processes, yet a comprehensive understanding …

… We thank members of the Wills lab for critical comments during the preparation of this
manuscript and support in frog husbandry. We thank Rosalind Bump for the 72hpa ass1 in situ …

A fundamental step in regeneration is rapid growth to replace lost tissue. Cells must generate
sufficient lipids, nucleotides, and proteins to fuel rapid cell division. To define metabolic …

Nodal signaling, mediated through SMAD transcription factors, is necessary for pluripotency
maintenance and endoderm commitment. We identified a new motif, termed SMAD complex-…

Regeneration of complex tissues is initiated by an injury-induced stress response, eventually
leading to activation of developmental signaling pathways such as Wnt signaling. How …

An instructive role for metabolism in embryonic patterning is emerging, although a role for
mitochondria is poorly defined. We demonstrate that mitochondrial oxidative metabolism …

The relevance of current education towards the needs of 21st century society is questioned
as most schools, especially in developing countries that offer their students homogenizing …

In ectodermal explants from Xenopus embryos, inhibition of BMP signaling is sufficient for
neural induction, leading to the idea that neural fate is the default state in the ectoderm. Many …

The suspension of face-to-face classes in universities and schools derived from the current
health crisis related to Covid-19 has prompted a process of migration of academic activities …