Background Valproate is widely accepted as a drug of first choice for patients with generalised
onset seizures, and its broad spectrum of efficacy means it is recommended for patients …

Background Carbamazepine is widely accepted as a drug of first choice for patients with
partial onset seizures. Several newer drugs possess efficacy against these seizure types but …

In a meta‐analysis of randomized controlled trials with time‐to‐event outcomes, an aggregate
data approach may be required for some or all included studies. Variation in the reporting …

Background The MRC Multicentre trial for Early Epilepsy and Single Seizures (MESS) showed
a reduced risk of further seizures in patients, for whom treatment with antiepileptic drugs …

Background There is evidence that certain antiepileptic drugs (AEDs) are teratogenic and
are associated with an increased risk of congenital malformation. The majority of women with …

: Purpose: Gabapentin (GBP), lamotrigine (LTG), tiagabine (TGB), topiramate (TPM),
vigabatrin (VGB), and zonisamide (ZNS) are all in use as “add‐on” treatment for patients with …

Background Accumulating evidence suggests an association between prenatal exposure to
antiepileptic drugs (AEDs) and increased risk of both physical anomalies and …

… N/Ag … Four substitutions are located in the GTPase domain, and two of these lie in a G …
Marson, Heather C. Mefford, Sahar Esmaeeli Nieh, Terence J. O’Brien, Ruth Ottman, Stephen …

… Two authors (SJN and AG) independently reviewed reasons for treatment failure for
classification as events or censored observations, and we resolved any disagreements by mutual …

Background People with epilepsy who became seizure-free while taking antiepileptic drugs
might consider discontinuing their medication, with the possibility of increased quality of life …