Matrix metalloproteinases (MMPs) were discovered because of their role in amphibian
metamorphosis, yet they have attracted more attention because of their roles in disease. Despite …

Mammalian organs are challenging to study as they are fairly inaccessible to experimental
manipulation and optical observation. Recent advances in three-dimensional (3D) culture …

Despite decades of study, there are still many unanswered questions about metastasis, the
process by which a localized cancer becomes a systemic disease. One of these questions is …

Mitochondrial morphology is determined by a dynamic equilibrium between organelle
fusion and fission, but the significance of these processes in vertebrates is unknown. The …

Carcinomas typically invade as a cohesive multicellular unit, a process termed collective
invasion. It remains unclear how different subpopulations of cancer cells contribute to this …

Epithelial organs are built through the movement of groups of interconnected cells. We
observed cells in elongating mammary ducts reorganize into a multilayered epithelium, migrate …

Recent genomic studies challenge the conventional model that each metastasis must arise
from a single tumor cell and instead reveal that metastases can be composed of multiple …

… We thank all members of the Ewald Laboratory for critical discussions and JC Ramirez for
assistance in quantifying the area of metastases and cryo-sectioning. We thank H. Zhang from …

The microvasculature consists of endothelial cells and their surrounding pericytes. Few studies
on the regulatory mechanisms of tumour angiogenesis have focused on pericytes. Here …

Breast cancer progression involves genetic changes and changes in the extracellular matrix
(ECM). To test the importance of the ECM in tumor cell dissemination, we cultured …