The clinical events resulting from atherosclerosis are directly related to the oxidation of lipids
in LDLs that become trapped in the extracellular matrix of the subendothelial space. These …

Atherosclerosis is an inflammatory disease of the large arteries that is the major cause of
cardiovascular disease (CVD) and stroke. Here, we review the current understanding of the …

Recent data support the hypothesis that the fatty streak develops in response to specific
phospholipids contained in LDL that become trapped in the artery wall and become oxidized as …

Metabolomics studies hold promise for the discovery of pathways linked to disease processes.
Cardiovascular disease (CVD) represents the leading cause of death and morbidity …

Intestinal microbiota metabolism of choline and phosphatidylcholine produces trimethylamine
(TMA), which is further metabolized to a proatherogenic species, trimethylamine-N-oxide (…

Trimethylamine (TMA) N-oxide (TMAO), a gut-microbiota-dependent metabolite, both enhances
atherosclerosis in animal models and is associated with cardiovascular risks in clinical …

Treating messenger RNA transcript abundances as quantitative traits and mapping gene
expression quantitative trait loci for these traits has been pursued in gene-specific ways. …

Many genetic variants influence complex traits by modulating gene expression, thus altering
the abundance of one or multiple proteins. Here we introduce a powerful strategy that …

Normal platelet function is critical to blood hemostasis and maintenance of a closed
circulatory system. Heightened platelet reactivity, however, is associated with cardiometabolic …

To study the effect of host genetics on gut microbiome composition, the MiBioGen consortium
curated and analyzed genome-wide genotypes and 16S fecal microbiome data from …