User profiles for A. J. Medlar
Alan MedlarHIIT Research Fellow, University of Helsinki Verified email at helsinki.fi Cited by 2564 |
[HTML][HTML] The CAFA challenge reports improved protein function prediction and new functional annotations for hundreds of genes through experimental screens
Background The Critical Assessment of Functional Annotation (CAFA) is an ongoing, global,
community-driven effort to evaluate and improve the computational annotation of protein …
community-driven effort to evaluate and improve the computational annotation of protein …
Mutations in the autoregulatory domain of β‐tubulin 4a cause hereditary dystonia
Dystonia type 4 (DYT4) was first described in a large family from Heacham in Norfolk with
an autosomal dominantly inherited whispering dysphonia, generalized dystonia, and a …
an autosomal dominantly inherited whispering dysphonia, generalized dystonia, and a …
Genetic testing in renal disease
D Bockenhauer, AJ Medlar, E Ashton, R Kleta… - Pediatric …, 2012 - Springer
A revolution is happening in genetics! The decoding of the first genome in 2003 was a large
international collaborative effort that took about 13 years at a cost of around $2.7 billion. Now…
international collaborative effort that took about 13 years at a cost of around $2.7 billion. Now…
AAI-profiler: fast proteome-wide exploratory analysis reveals taxonomic identity, misclassification and contamination
We present AAI-profiler, a web server for exploratory analysis and quality control in comparative
genomics. AAI-profiler summarizes proteome-wide sequence search results to identify …
genomics. AAI-profiler summarizes proteome-wide sequence search results to identify …
Phospholipase A2 receptor (PLA2R1) sequence variants in idiopathic membranous nephropathy
…, H Debiec, HC Stanescu, AJ Medlar… - Journal of the …, 2013 - journals.lww.com
The M-type receptor for phospholipase A2 (PLA2R1) is the major target antigen in idiopathic
membranous nephropathy (iMN). Our recent genome-wide association study showed that …
membranous nephropathy (iMN). Our recent genome-wide association study showed that …
[HTML][HTML] Nephrocalcinosis (enamel renal syndrome) caused by autosomal recessive FAM20A mutations
…, A Asselin, A Picard, A Coulomb, AJ Medlar… - Nephron …, 2013 - karger.com
Background/Aims: Calcium homeostasis requires regulated cellular and interstitial systems
interacting to modulate the activity and movement of this ion. Disruption of these systems in …
interacting to modulate the activity and movement of this ion. Disruption of these systems in …
[PDF][PDF] Pannzer 2: Annotate a complete proteome in minutes
As high-throughput sequencing has become increasingly efficient, downstream analysis has
become the main bottleneck in genome sequencing projects. For example, a critical and …
become the main bottleneck in genome sequencing projects. For example, a critical and …
Manycore Algorithms for Genetic Linkage Analysis
AJ Medlar - 2012 - discovery.ucl.ac.uk
… I, Alan John Medlar confirm that the work presented in this thesis is my own. Where information
has been derived from other sources, I confirm that this has been indicated in the thesis. …
has been derived from other sources, I confirm that this has been indicated in the thesis. …
[HTML][HTML] Risk HLA-DQA1 and PLA2R1 Alleles in Idiopathic Membranous Nephropathy
HC Stanescu, M Arcos-Burgos, A Medlar… - … England Journal of …, 2011 - Mass Medical Soc
Background Idiopathic membranous nephropathy is a major cause of the nephrotic syndrome
in adults, but its etiologic basis is not fully understood. We investigated the genetic basis of …
in adults, but its etiologic basis is not fully understood. We investigated the genetic basis of …
Autoinflammatory periodic fever, immunodeficiency, and thrombocytopenia (PFIT) caused by mutation in actin-regulatory gene WDR1
…, H Jones, E Omoyinmi, KC Gilmour, A Medlar… - Journal of Experimental …, 2017 - rupress.org
The importance of actin dynamics in the activation of the inflammasome is becoming increasingly
apparent. IL-1β, which is activated by the inflammasome, is known to be central to the …
apparent. IL-1β, which is activated by the inflammasome, is known to be central to the …