The success of immune checkpoint blockade in patients with a wide variety of malignancies
has changed the treatment paradigm in oncology. However, combination therapies with …

Improving efficacy of immune checkpoint blockade for cancer can be facilitated by
combining these agents with each other and/or with other conventional or targeted therapies. …

Immune checkpoint inhibitors 1 result in impressive clinical responses 2 , 3 , 4 , 5 , but
optimal results will require combination with each other 6 and other therapies. This raises …

Ever since Stephen Paget’s 1889 hypothesis, metastatic organotropism has remained one
of cancer’s greatest mysteries. Here we demonstrate that exosomes from mouse and human …

By means of in vivo selection, transcriptomic analysis, functional verification and clinical
validation, here we identify a set of genes that marks and mediates breast cancer metastasis to …

Much of our understanding on resistance mechanisms to conventional cancer therapies such
as chemotherapy and radiation has focused on cell intrinsic properties that antagonize the …

Heterodimerization between members of the Bcl-2 family of proteins is a key event in the
regulation of programmed cell death. The molecular basis for heterodimer formation was …

The molecular basis for breast cancer metastasis to the brain is largely unknown 1 , 2 . Brain
relapse typically occurs years after the removal of a breast tumour 2 , 3 , 4 , suggesting that …

T cell activation through the TCR can result in either cell proliferation or cell death. The role
of costlmulatory receptors in regulating T cell survival has not been defined. Here, we …

Inflammatory gene expression following genotoxic cancer therapy is well documented, yet
the events underlying its induction remain poorly understood. Inflammatory cytokines modify …