User profiles for A. L. Bruzos

Alicia L. Bruzos

BSc. in Biology; MSc. in Bioinformatics; PhD. in Molecular Medicine
Verified email at crick.ac.uk
Cited by 2145

[HTML][HTML] Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition

…, J Rodriguez-Castro, A Dueso-Barroso, AL Bruzos… - Nature …, 2020 - nature.com
About half of all cancers have somatic integrations of retrotransposons. Here, to characterize
their role in oncogenesis, we analyzed the patterns and mechanisms of somatic …

Somatic evolution of marine transmissible leukemias in the common cockle, Cerastoderma edule

AL Bruzos, M Santamarina, D Garcia-Souto, S Díaz… - Nature Cancer, 2023 - nature.com
Transmissible cancers are malignant cell lineages that spread clonally between individuals.
Several such cancers, termed bivalve transmissible neoplasia (BTN), induce leukemia-like …

[HTML][HTML] Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture

…, B Rodriguez-Martin, A Oitaben, AL Bruzos… - Nature …, 2021 - nature.com
Most cancers are characterized by the somatic acquisition of genomic rearrangements
during tumour evolution that eventually drive the oncogenesis. Here, using multiplatform …

[HTML][HTML] Author Correction: Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition

…, J Rodriguez-Castro, A Dueso-Barroso, AL Bruzos… - nature genetics, 2023 - nature.com
In the published version of this paper, the members of the Pan-Cancer Analysis of Whole
Genomes (PCAWG) Consortium were listed in the Supplementary Information; however, these …

Mitochondrial genome sequencing of marine leukaemias reveals cancer contagion between clam species in the Seas of Southern Europe

D Garcia-Souto, AL Bruzos, S Diaz, S Rocha… - Elife, 2022 - elifesciences.org
… To address these questions, Garcia- Souto, Bruzos, Díaz et al. gathered over 400 … To
determine whether the cancer still affected both species, Garcia- Souto, Bruzos, Díaz et al. …

Germline determinants of the somatic mutation landscape in 2,642 cancer genomes

…, A Baez-Ortega, M Bailey, M Bosio, AL Bruzos… - BioRxiv, 2017 - biorxiv.org
Cancers develop through somatic mutagenesis, however germline genetic variation can
markedly contribute to tumorigenesis via diverse mechanisms. We discovered and phased 88 …

Assessing the elemental fingerprints of cockle shells (Cerastoderma edule) to confirm their geographic origin from regional to international spatial scales

F Ricardo, R Mamede, AL Bruzos, S Díaz… - Science of the Total …, 2022 - Elsevier
Geographic origin is directly linked to the quality and commercial value of bivalves. The
globalization of the seafood trade and the increasing number of fraudulent practices in the …

[HTML][HTML] The first high-density genetic map of common cockle (Cerastoderma edule) reveals a major QTL controlling shell color variation

M Hermida, D Robledo, S Díaz, D Costas, AL Bruzos… - Scientific Reports, 2022 - nature.com
Shell color shows broad variation within mollusc species and despite information on the
genetic pathways involved in shell construction and color has recently increased, more studies …

[HTML][HTML] Mosaic BRAF Fusions Are a Recurrent Cause of Congenital Melanocytic Nevi Targetable by MAPK Pathway Inhibition

SB Martin, S Polubothu, AL Bruzos, G Kelly… - Journal of Investigative …, 2024 - Elsevier
Among children with multiple congenital melanocytic nevi, 25% have no established genetic
cause, of whom many develop a hyperproliferative and severely pruritic phenotype resistant …

The evolution of two transmissible leukaemias colonizing the coasts of Europe

AL Bruzos, M Santamarina, D García-Souto, S Díaz… - BioRxiv, 2022 - biorxiv.org
Transmissible cancers are malignant cell clones that spread among individuals through
transfer of living cancer cells. Several such cancers, collectively known as bivalve transmissible …